Suggested antimicrobial regimens for the most commonly isolated pathogens causing osteoarticular infections in infants and children when results of culture and susceptibility testing are known

Pathogen	Parenteral agents	Oral agents
Staphylococcus aureus
Methicillin-susceptible	Cefazolin Nafcillin Oxacillin	Cephalexin Cloxacillin (not available in the United States) Dicloxacillin Clindamycin^*
Methicillin-resistant
Clindamycin-susceptible	Vancomycin Clindamycin	Clindamycin
Clindamycin-resistant^¶	Vancomycin Linezolid Daptomycin^Δ	Linezolid Trimethoprim-sulfamethoxazole
Streptococcus agalactiae (Group B Streptococcus)
	Penicillin	Oral therapy not suggested in infants
Streptococcus pyogenes (Group A Streptococcus)
	Penicillin Ampicillin	Penicillin Amoxicillin
Streptococcus pneumoniae (Pneumococcus)
Penicillin-susceptible	Penicillin	Penicillin Amoxicillin
Penicillin-nonsusceptible	Cefotaxime Ceftriaxone Clindamycin^* Linezolid	Clindamycin^* Linezolid
Kingella kingae
	Penicillin Cefazolin Cefotaxime Ceftriaxone	Penicillin Cephalexin Cefixime
Haemophilus influenzae type b
	Cefotaxime Ceftriaxone Cefuroxime	Amoxicillin (if susceptible) Cefixime

* If isolate is clindamycin-susceptible.

¶ Clindamycin should not be used even if D-test is negative.

Δ Daptomycin should not be used in children with concomitant pulmonary involvement. It is not approved for the treatment of osteoarticular infections in children; the appropriate dose has not been established.

Graphic 71347 Version 15.0

خرید پکیج

Suggested antimicrobial regimens for the most commonly isolated pathogens causing osteoarticular infections in infants and children when results of culture and susceptibility testing are known