American Heart Association (AHA) | European Society of Cardiology (ESC) | |
Adult (MIC >0.12 mcg/mL)¶ | Pediatric (MIC >0.1 mcg/mL)¶ | Adult (MIC ≥0.25 mcg/mL)¶ |
Combination therapy: Either Aqueous penicillin G 24 million units per 24 hours IV either continuously or in 4 or 6 divided doses for 6 weeks or Ampicillin 2 g IV every 4 hours for 6 weeks or CeftriaxoneΔ 2 g/24 hours IV in 1 dose for six weeks plus Gentamicin◊§ 3 mg/kg per 24 hours IV or IM in 1 dose for 6 weeks Monotherapy: Vancomycin¥ 30 mg/kg per 24 hours IV in 2 divided doses for 6 weeks | Combination therapy: Either Aqueous penicillin G 200,000 to 300,000 units/kg per 24 hours IV in 6 divided doses (maximum dose: 24 million units per 24 hours) for 6 weeks or Ampicillin 200 to 300 mg/kg per 24 hours IV divided in 4 or 6 divided doses (maximum dose: 12 g per 24 hours) for 6 weeks or Ceftriaxone 100 mg/kg per 24 hours IV in 2 divided doses or 80 mg/kg in 1 daily dose (maximum dose: 4 g per 24 hours; if dose is >2 g per 24 hours, use divided dosing every 12 hours) for 6 weeks plus Gentamicin◊ 3 to 6 mg/kg per 24 hours IV in 3 divided doses for 6 weeks Beta-lactam-intolerant patients: Vancomycin¥ 40 mg/kg per 24 hours IV in 2 or 3 divided doses (maximum dose: 2 g per 24 hours unless levels are inappropriately low) for 6 weeks plus gentamicin (dosing as above) for first 2 weeks | Combination therapy: Either Aqueous penicillin G 24 million units per 24 hours IV in 4 or 6 divided doses or continuously for 6 weeks or Amoxicillin 200 mg/kg per 24 hours IV in 4 or 6 divided doses for 6 weeks or CeftriaxoneΔ 2 g per 24 hours IV in 1 dose for 6 weeks or Ampicillin 12 g per 24 hours (or 200 mg/kg per 24 hours) in 4 or 6 divided doses for 6 weeks or Vancomycin¥ 30 mg/kg per 24 hours IV in 2 doses for 6 weeks plus Gentamicin◊§ 3 mg/kg per 24 hours IV or IM in 1 dose for 6 weeks |
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