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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Clinical manifestations of Lyme disease

Clinical manifestations of Lyme disease
Early localized disease, occurring a few days to one month after the tick bite*
Erythema migrans - occurs in approximately 80 percent of patients
Associated symptoms and signs may include: fatigue, malaise, lethargy, mild headache, mild neck stiffness, myalgias, arthralgias, regional lymphadenopathy
Early disseminated disease, occurring weeks to months after the tick bite*Δ
Carditis - about 1 percent of patients reported to the CDC
Manifestations include AV nodal block, mild cardiomyopathy or myopericarditis
Neurologic disease - occurs in approximately 15 percent of untreated patients
Manifestations include lymphocytic meningitis, cranial neuropathy (most often facial, can be bilateral), peripheral neuropathy; rarely myelitis or encephalitis
Musculoskeletal involvement - occurs in approximately 60 percent of untreated patients
Manifestations include migratory arthralgias
Skin involvement - multiple erythema migrans lesionsΔ, borrelial lymphocytoma (in Europe)
Lymphadenopathy - regional or generalized
Eye involvement§ - conjunctivitis, iritis, choroiditis, vitritis, retinitis
Liver disease - liver function test abnormalities, hepatitis
Kidney disease - microhematuria, asymptomatic proteinuria
Late disease, occurring months to years after the tick bite*
Musculoskeletal symptoms - approximately 60 percent of untreated patients develop intermittent monoarticular or oligoarticular arthritis; approximately 10 percent of untreated patients develop persistent monoarthritis, usually affecting the knee
Neurologic disease - incidence has not been established
Peripheral neuropathy or encephalomyelitis (both rare)
Cutaneous involvement - acrodermatitis chronica atrophicans, morphea/localized scleroderma-like lesions (both described only in Europe)
CDC: United States Centers for Disease Control and Prevention.
* Only about 25 percent of patients with erythema migrans recall the tick bite that transmitted Lyme disease.
¶ Can occur in the absence of any prior features of Lyme disease.
Δ The multiple erythema migrans lesions of early disseminated disease typically occur days to weeks following infection.
Incidence following treated erythema migrans is not known but is very low.
§ Observation based on individual case reports.
Graphic 72018 Version 11.0

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