Oral antibiotics for treatment of travelers' diarrhea in adults

Agent	Dose	Duration	Comment
Azithromycin	1000 mg once	Single dose*	Preferred for dysentery or febrile diarrhea, travelers from Southeast Asia, and pregnant women. The 1000 mg dose may be associated with nausea.
Azithromycin	500 mg once daily	3-day course
Rifaximin	200 mg 3 times daily	3-day course	Not for use with dysentery or febrile diarrhea.
Rifamycin	2 (194 mg) tablets twice daily	3-day course	Not for use with dysentery or febrile diarrhea.
Levofloxacin	500 mg once daily	Single dose* or 3-day course	Fluoroquinolones are associated with multiple adverse events. Resistance to fluoroquinolones in enteric pathogens is increasing worldwide, limiting their utility.
Ciprofloxacin	750 mg once	Single dose*
Ciprofloxacin	500 mg twice daily	3-day course
Ofloxacin	400 mg once daily	Single dose* or 3-day course

* If symptoms have not resolved after 24 hours, the regimen can be extended to complete a 3-day course (using the dosing listed for the 3-day course).

Riddle MS, Connor BA, Beeching NJ, et al. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. J Travel Med 2017; 24:S57.

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Oral antibiotics for treatment of travelers' diarrhea in adults