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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Undifferentiated rheumatic diseases and overlap syndromes

Undifferentiated rheumatic diseases and overlap syndromes
Clinical scenario Description Examples and synonyms
Nonclassic or early presentations of specific syndromes Patients who present with features suggestive of a specific condition (eg, systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], or systemic sclerosis) but have enough diagnostic uncertainty to preclude a diagnosis
  • Nonclassic SLE; SLE-like, SLE variant, or near, borderline, latent, incipient, incomplete, possible, or probable SLE[1,2]
  • Nonclassic RA, palindromic rheumatism[3], pre-RA, early RA
  • Nonclassic scleroderma, prescleroderma[4]
Undifferentiated arthritis syndromes Patients with inflammatory arthritis who do not clearly fit into specific subtypes of arthritis
  • Undifferentiated polyarthritis syndrome
  • Undifferentiated spondyloarthritis
Overlap syndromes Patients who have systemic features that overlap 2 or more specific, recognized entities
  • RA-SLE, rhupus
  • Scleroderma-polymyositis/dermatomyositis
  • Scleroderma-SLE
  • Scleroderma-RA
  • Other scleroderma overlaps
  • Polymyositis overlaps
  • Juvenile idiopathic arthritis (JIA)-SLE
  • Sjögren's disease overlaps
Mixed connective tissue disease (MCTD) Patients who have symptoms of multiple types of autoimmune conditions in the presence of high-titer anti-U1 ribonucleoprotein (RNP) antibodies
  • Patients with features of SLE, RA, systemic sclerosis, and polymyositis who have anti-U1 RNP antibodies
Undifferentiated connective tissue disease (USRD) Patients with features suggestive of systemic autoimmune disease who do not otherwise fit into the above categories
  • (Early) undifferentiated connective tissue, collagen vascular, or autoimmune disease
References:
  1. Greer JM, Panush RS. Incomplete lupus erythematosus. Arch Intern Med 1989; 149:2473.
  2. Lambers WM, Westra J, Jonkman MF, et al. Incomplete lupus erythematosus: What remains after application of the American College of Rheumatology and systemic lupus international collaborating clinics criteria? Arthritis Care Res 2020; 72:607.
  3. Ellingwood I, Schieir O, Valois MF, et al. Palindromic rheumatism frequently precedes early rheumatoid arthritis. Results from an incident cohort. ACR Open Rheumatology 2019; 1:614.
  4. Valentini G, Pope JE. Undifferentiated connective tissue disease at risk for systemic sclerosis: Which patients might be labeled prescleroderma? Autoimmunity Rev 2020; 19:102659.
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