Nonclassic or early presentations of specific syndromes | Patients who present with features suggestive of a specific condition (eg, systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], or systemic sclerosis) but have enough diagnostic uncertainty to preclude a diagnosis | - Nonclassic SLE; SLE-like, SLE variant, or near, borderline, latent, incipient, incomplete, possible, or probable SLE[1,2]
- Nonclassic RA, palindromic rheumatism[3], pre-RA, early RA
- Nonclassic scleroderma, prescleroderma[4]
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Undifferentiated arthritis syndromes | Patients with inflammatory arthritis who do not clearly fit into specific subtypes of arthritis | - Undifferentiated polyarthritis syndrome
- Undifferentiated spondyloarthritis
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Mixed connective tissue disease (MCTD) | Patients who have symptoms of multiple types of autoimmune conditions in the presence of high-titer anti-U1 ribonucleoprotein (RNP) antibodies | - Patients with features of SLE, RA, systemic sclerosis, and polymyositis who have anti-U1 RNP antibodies
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Undifferentiated connective tissue disease (USRD) | Patients with features suggestive of systemic autoimmune disease who do not otherwise fit into the above categories | - (Early) undifferentiated connective tissue, collagen vascular, or autoimmune disease
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