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Clinical features that may indicate intracranial pathology in children and adolescents with headache

Clinical features that may indicate intracranial pathology in children and adolescents with headache
Headache characteristics
Headache awakens the child or occurs consistently upon awakening from sleep
Short or paroxysmal headache; thunderclap headache (uncommon in children)
Associated neurologic signs and symptoms (eg, persistent nausea/vomiting, altered mental status, ataxia, etc)
Headache worsened in recumbent position or by cough, micturition, defecation, or physical activity
Absence of aura
Chronic progressive headache pattern
Change in quality, severity, frequency, or pattern of headache
Occipital headache
Recurrent localized headache
Lack of response to medical therapy
Headache duration of less than six months
Patient history
Inadequate history (description of headache and relative features)
Risk factor for intracranial pathology (eg, sickle cell disease, immune deficiency, malignancy or history of malignancy, coagulopathy, cardiac disease with right-to-left intracardiac shunt, head trauma, neurofibromatosis type 1, tuberous sclerosis complex, pre-existing hydrocephalus or shunt)
Age <6 years
Personality change
Deterioration of school work
Associated symptoms in the neck or back
Family history
Absence of family history of migraine
Examination findings
Child uncooperative (unable to complete neurologic examination)
Abnormal neurologic examination (eg, ataxia, weakness, diplopia, abnormal eye movements, other focal signs)
Papilledema or retinal hemorrhages
Growth abnormalities (increased head circumference, short stature or deceleration of linear growth, abnormal pubertal progression, obesity)
Nuchal rigidity
Signs of trauma
Cranial bruits
Skin lesions that suggest a neurocutaneous syndrome (neurofibromatosis, tuberosis sclerosis complex)
Data from:
  1. Lewis DW, Ashwal S, Dahl G, et al. Practice parameter: Evaluation of children and adolescents with recurrent headaches: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002; 59:490.
  2. Newton RW. Childhood headache. Arch Dis Child Educ Pract Ed 2008; 93:105.
  3. Strasburger VC, Brown RT, Braverman PK, et al. Headache. In: Adolescent Medicine: A Handbook for Primary Care, Lippincott Williams & Wilkins, Philadelphia 2006. p.25.
  4. Wilne S, Koller K, Collier J, et al. The diagnosis of brain tumours in children: A guideline to assist healthcare professionals in the assessment of children who may have a brain tumour. Arch Dis Child 2010; 95:534.
  5. Seshia SS, Abu-Arafeh I, Hershey AD. Tension-type headache in children: The Cinderella of headache disorders! Can J Neurol Sci 2009; 36:687.
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