INTRODUCTION —
The lifetime risk of a foot ulcer in patients with diabetes (type 1 or 2) may be as high as 34 percent [1-3]. Diabetic foot ulcers are a major cause of morbidity [4], accounting for at least two-thirds of all nontraumatic amputations performed in the United States [5,6]. Infected or ischemic diabetic foot ulcers account for approximately 25 percent of all hospital stays for patients with diabetes [7]. Based on data from the World Health Organization, lower extremity complications of diabetes constitute a top ten condition in terms of years lived with disability [8,9]. Moreover, patients with diabetes with or without a diabetic foot ulcer have increased rates of depression, and expressing signs of depression is associated with an increased risk of diabetic foot ulcers [10,11]. These observations illustrate the importance of prompt and appropriate treatment of foot ulcers in patients with diabetes.
The management of diabetic foot ulcers, including local wound care, use of mechanical offloading, treatment of infection, and indications for revascularization, are reviewed here. The evaluation of the diabetic foot and specific management of the threatened limb are reviewed separately. (See "Evaluation of the diabetic foot" and "Management of chronic limb-threatening ischemia".)
ETIOLOGY —
Risk factors that can lead to foot wounds in patients with diabetes include loss of protective sensation due to neuropathy, prior ulcers or amputations, foot deformity leading to excess pressure, external trauma, infection, and the effects of chronic ischemia, typically due to peripheral artery disease [1]. Patients with diabetes also have an increased risk for nonhealing related to mechanical and cytogenic factors, as well as a high prevalence of peripheral artery disease. (See "Evaluation of the diabetic foot", section on 'Risk factors'.)
ULCER CLASSIFICATION —
The first step in managing diabetic foot ulcers is assessing, grading, and classifying the ulcer. Classification is based on clinical evaluation of the extent and depth of the ulcer and the presence of infection or ischemia, which determine the nature and intensity of treatment. To assess for ischemia, all patients with diabetic foot ulcers should have ankle-brachial index and toe pressure measurements.
University of Texas System — The University of Texas (UT, San Antonio) in the United States introduced a clinical classification system for diabetic foot wounds that evaluates wound depth, the presence of infection, and peripheral arterial occlusive disease for every category of the wound assessment [12]. The UT system was the first diabetic foot ulcer classification to be validated [13]. This system updated the Wagner classification [14]. (See 'Wagner, PEDIS, and others' below.)
Grade:
●Grade 0: Pre- or post-ulcerative (Stages A to D) (picture 1)
●Grade 1: Full-thickness ulcer not involving the tendon, capsule, or bone (Stages A to D) (picture 2)
●Grade 2: Tendon or capsular involvement without bone palpable (Stages A to D) (picture 3 and picture 4)
●Grade 3: Probes to bone (Stages A to D) (picture 5)
Stage:
●A: Noninfected
●B: Infected
●C: Ischemic
●D: Infected and ischemic (picture 6)
Threatened limb classification: WIfI — To provide a more quantitative assessment of peripheral artery disease (PAD) as a predictor and contributor to lower extremity pathology, the Society for Vascular Surgery has proposed the structure of the Wound/Ischemia/Foot Infection (WIfI) system. The classification can be visualized as three intersecting rings of risk (figure 1) [15]. Scores are assigned on a "none/mild/moderate/severe basis (0/1/2/3)" using multiple specified criteria in the same fundamental categories as the University of Texas System (see 'University of Texas System' above) [16]. This "threatened limb" system includes, in particular, more detailed measures and criteria for grading vascular status. It has been validated in four separate studies and shows promise as a pragmatic means to assess the likelihood of morbidity in at-risk limbs (table 1). The quantitative scores for these individual categories can help identify the relative importance of the various factors underlying risk to a limb at a given point in time. In applying the WIfI system, it is recommended that patients with and without diabetes be considered in separate categories and that the presence or absence of neuropathy be additionally noted in patients with diabetes [16]. While the specifics of what constitutes "none, mild, moderate, and severe" may change over time, the basic principles are likely to prove durable [15,17]. (See "Classification of acute and chronic lower extremity ischemia", section on 'WIfI (Wound, Ischemia, foot Infection)'.)
Wagner, PEDIS, and others — An early and often still used classification system at hyperbaric-based wound healing centers was originally proposed by Wagner [18]. This classification was based upon clinical evaluation (depth of ulcer and presence of necrosis) alone and did not account for variability in the vascular status of the foot. The ulcer classification is as follows:
●Grade 1: Superficial ulcer – Skin and subcutaneous tissue only
●Grade 2: Deep ulcer to tendon, muscle, joint capsule, or bone
●Grade 3: Deep ulcer with abscess, osteomyelitis, or tendinitis
●Grade 4: Partial foot gangrene
●Grade 5: Whole foot gangrene
The Wagner system is predictive of poor outcomes, but only up to grade 3 [14]. It has fallen out of widespread use because of the lack of specificity to describe coexistent depth, infection, and ischemia.
The International Working Group on the Diabetic Foot proposed classifying all ulcers according to the following categories: perfusion, extent, depth, infection, and sensation (PEDIS) [19]. The PEDIS system is primarily used for research purposes. Other ulcer classification systems have also been described [20-22].
MANAGEMENT OVERVIEW —
Our management approach is consistent with multidisciplinary guidelines for the management of the diabetic foot [23,24]. (See 'Society guideline links' below.)
The management of diabetic foot ulcers begins with a comprehensive assessment of the ulcer and the patient's overall medical condition (algorithm 1). Most patients with diabetes over age 40 should be offered measures to reduce their risk of developing cardiovascular complications. (See "Overview of general medical care in nonpregnant adults with diabetes mellitus", section on 'Reducing the risk of macrovascular disease'.)
Evidence of infection, underlying neuropathy, peripheral artery disease, edema, malnutrition, and any bony deformities should be actively sought and addressed systematically [25,26]. The incidence of neuropathic (Charcot) arthropathy may be as high as 13 percent in patients with diabetes [27]. (See "Diabetic neuroarthropathy" and "Surgical management of neuropathic arthropathy (Charcot foot)".)
For patients with evidence of arterial insufficiency, we suggest referral to a vascular specialist.
While it stands to reason that effective glucose control and adequate nutrition are important in healing diabetic foot wounds, there are few data to support either assumption. There are no randomized trials to support that glucose control affects healing [28]. A trial evaluating the effectiveness of liquid oral protein supplementation failed to show a difference in healing between main groups but reported a significantly greater likelihood of healing in a subset of patients with low albumin or ischemia [29,30]. In addition, an analysis of the Diabetes Control and Complications Trial (DCCT) suggested that intensive glucose control might reduce the incidence of new ulceration by more than 23 percent [31].
Ulcer/wound care is based upon the wound classification. (See 'Ulcer classification' above and 'Local wound care' below.)
Any ulcer that is subjected to sustained or frequent pressure and stress (ie, pressure-related heel ulcers or medial/lateral foot ulcers) or repetitive moderate pressure (plantar foot ulcers) will benefit from pressure reduction, which is accomplished with mechanical offloading. Several methods are available to achieve mechanical offloading, including total contact casts, cast walkers, wedge shoes, and bedrest. Following surgery, total contact casting and cast walkers are better alternatives to prolonged bed rest for the relief of pressure as they allow for the benefits and convenience of continued ambulation. (See 'Mechanical offloading' below.)
For some patients, successful offloading of a diabetic ulcer cannot be adequately achieved by mechanical devices alone. In such cases, surgical correction of the deformity may be required. Interventions include hammertoe corrections, bunion corrections, Achilles tendon or gastrocnemius lengthening, and Charcot foot reconstructions. (See "Diabetic neuroarthropathy" and "Surgical management of neuropathic arthropathy (Charcot foot)".)
After appropriately addressing debridement, pressure offloading, infection, and ischemia, there are a number of adjunctive therapies that may prove helpful in augmenting wound healing. (See "Local care of diabetic foot ulcers", section on 'Adjuncts to wound healing'.)
Whether such management can be accomplished in an outpatient setting and when admission to the hospital is needed depends upon the skill set of the local wound care team, the resources available, and the personality and life circumstances of the patient.
LOCAL WOUND CARE —
Local care includes sharp debridement and appropriate dressing management. When clinicians with expertise in sharp debridement are available, we prefer this method for debridement for diabetic foot wounds as with other wounds requiring debridement. Wound care is based on the ulcer classification (algorithm 1). We use the wound, ischemia, and foot infection (WIfI [17]) classification, which classifies the wound based on the presence and severity of the wound, infection, and ischemia (figure 1), and which can help set realistic expectations for healing and amputation risk (table 1). (See 'Ulcer classification' above.)
●Noninfected, nonischemic wounds. (See "Local care of diabetic foot ulcers", section on 'Noninfected, nonischemic wounds'.)
●Ischemic, noninfected wounds. (See 'Ischemia and revascularization' below and "Local care of diabetic foot ulcers", section on 'Ischemic, noninfected wounds'.)
●Infected, nonischemic. (See 'Managing infection' below and "Local care of diabetic foot ulcers", section on 'Infected, nonischemic wounds'.)
●Infected and ischemic. (See 'Managing infection' below and 'Ischemia and revascularization' below and "Local care of diabetic foot ulcers", section on 'Infected, ischemic wounds'.)
Allowable time course for primary healing — In clinical practice, measurements of a patient's ulcer size should be taken at every visit so that comparisons can be made and progress documented. The surface area of a diabetic foot ulcer should decrease in size at a rate of approximately 1 to 2 percent a day. Thus, appropriate local wound care should achieve a greater than 40 to 50 percent surface area reduction or reduction of ulcer depth by four weeks [32]. If this rate of progress is not observed in our system, the patient's care is transferred from the local team to a wound consultant who works with the patient's primary care clinician to address issues such as glycemic control, edema, and other aspects of general health and nutrition. Ulcers that still do not improve should be reevaluated for ongoing soft tissue infection or osteomyelitis, impaired extremity vascular flow, and, most commonly, the need for more effective offloading or surgical debridement.
Coordination of care — Coordination among care providers is important. Meta-analyses have provided evidence that interdisciplinary teams have a profound impact on reducing the rate of amputation [33,34]. In a study of 10 Department of Veterans Affairs (VA) medical centers, decreased rates of amputation were seen in programs with the highest scores for availability of clinical protocols, educational seminars, discharge planning, and quality of care meetings [35]. Clinical teams may include podiatric, vascular, plastic, and orthopedic surgeons. These surgeons, who focus on WIfI-dominant conditions, may be assisted by shoe specialists/prosthetists, physical therapists, nurse specialists, and nutritionists/dietitians. In addition, primary care physicians, infectious disease physicians, nephrologists, and diabetologists all play significant roles in limb preservation units [36].
Follow-up care and ulcer prevention — Once a patient has healed an ulcer, they remain at a very high risk for re-ulceration. Once healed, ulcer recurrence is 40 percent at one year, 66 percent at three years, and up to 75 percent at five years [4]. Therefore, people with healed ulcers should be considered "in remission," a term that better communicates the lifetime of visits (often bimonthly) needed to reduce the risk for severe recurrence, if not all ulcer recurrences [1,37,38]. The goals of long-term surveillance and care are to maximize ulcer-free, hospital-free, and activity-rich days.
Ongoing counseling regarding preventive foot care should be given to any patient whose feet are at risk for further ulcer development, particularly patients with existing neuropathy (table 2). Several measures can markedly diminish ulcer formation, such as avoiding poorly fitting shoes, not walking barefoot, and stopping smoking. (See "Evaluation of the diabetic foot", section on 'Risk factors' and "Evaluation of the diabetic foot", section on 'Preventive foot care' and 'Mechanical offloading' below.)
Certain oral diabetes agents (ie, SGLT2 inhibitors) may be associated with an increased risk of amputation compared with other oral treatments for type 2 diabetes [39]. If the patient is taking these agents, it should be discontinued. This issue is discussed in detail separately. (See "Sodium-glucose cotransporter 2 inhibitors for the treatment of hyperglycemia in type 2 diabetes mellitus", section on 'Amputations'.)
MECHANICAL OFFLOADING —
All ulcers subjected to sustained or frequent pressure and stress (ie, pressure-related heel ulcers or medial/lateral foot ulcers) or repetitive moderate pressure (plantar foot ulcers) benefit from pressure reduction, which is accomplished with mechanical offloading. Offloading devices include total contact casts, cast walkers, shoe modifications, and other devices to assist in ambulation [40]. Although nonremovable pressure-relieving treatments improve healing, in clinical practice, the type of offloading that is used depends largely on local resources, such as whether there is a surgeon who is skilled at contact casting or a practitioner (eg, podiatrist) who can fit the patient with customized footwear. In the absence of such expertise, a removable cast walker may be the best option.
Evidence from randomized trials supports the use of total contact casts and nonremovable cast walkers for relief of pressure to improve the healing of diabetic foot ulcers. A 2013 Cochrane review evaluated 14 trials comparing various forms of pressure-relieving treatments (nonremovable, removable) and dressings [41,42]. In five trials, the likelihood of wound healing was significantly better at 12 weeks for nonremovable, pressure-relieving casts compared with removable devices or dressings (relative risk [RR] 1.17, 95% CI 1.01-1.36). In one trial, no significant differences were found between different types of nonremovable pressure-relieving treatments.
Total contact cast — A total contact cast is a padded fiberglass or plaster shell designed to take pressure off the heel or elsewhere on the foot by averaging the pressure across the sole of the foot (ie, eliminates high- and low-pressure regions by providing contact at all points) or to generally unweight the entire foot through a total contact fit at the calf. Disadvantages of total contact casting include expertise needed in applying the cast, inability to inspect the foot frequently, inconvenience in activities of daily living (eg, bathing), and the risk of developing a secondary ulcer in an ill-fitting cast (particularly in patients with neuropathy) [25]. Frequent cast changes may be needed to avoid complications. Total contact casts should not be used in patients with infected ulcers or wounds, osteomyelitis, peripheral ischemia (ankle-brachial index <0.6), bilateral ulceration, lower extremity amputation, or heel ulceration [43].
Based upon randomized trials, total contact casting enhances diabetic ulcer healing and is the standard for relieving pressure from the forefoot [41,42,44-50]. As an example, in a trial of offloading modalities in 63 patients with diabetes and superficial, noninfected, nonischemic plantar ulcers, the proportion of ulcers that were healed at 12 weeks was significantly higher in those randomly assigned to a total contact cast compared with a half-shoe or removable cast walker (90 versus 58 and 65 percent, respectively) [46]. Patients with a total contact cast also had faster healing. Another small trial found that, compared with the casting alone, casting combined with Achilles tendon lengthening resulted in significantly fewer ulcer recurrences at seven months (15 versus 59 percent) and at two years (38 versus 81 percent) [51].
Cast walkers — An alternative to total contact casting is a prefabricated brace called a cast walker that is designed to maintain a total contact fit (figure 2). Several cast walkers (nonremovable, removable) are commercially available and provide the capability to offload the foot in a manner similar to contact casts. A significant disadvantage of the cast walker is poor patient compliance if the cast walker is removed [52].
Prefabricated products are at least as good as total contact casting for offloading the foot and equalizing foot pressures when the foot anatomy is normal, as illustrated in the studies below, but data are not available demonstrating these effects for patients with diabetic foot deformities.
●One study compared plantar foot pressure metrics in a standard shoe, total contact cast, and cast walker (pneumatic) [53]. Five plantar foot sensors were placed at the first, third, and fifth metatarsal heads, fifth metatarsal base, and mid-plantar heel of 10 healthy male subjects who walked at a constant speed over a distance of 280 meters. Peak pressures were significantly reduced in the pneumatic walker compared with the standard shoe for all sensor locations to an equal or greater degree compared with the total contact cast in all sensor locations.
●Another study measured foot pressures using an in-shoe pressure measurement system (Novel Pedar) in 18 healthy participants while wearing a cast walker or total contact cast [54]. Peak foot pressures using the cast walker were significantly reduced in the forefoot (12 versus 18 newtons [N]/cm2) and foot as a whole (14 versus 19 N/cm2) compared with a fiberglass total contact cast, but no differences were found for the heel or midfoot.
Cast walkers have been used for the treatment of neuropathic plantar ulcers, but these devices, thus far, have not been found to be superior to total contact casting in randomized trials. In one trial, the rate of ulcer healing was significantly higher in those randomly assigned to total contact casting compared with a half-shoe or removable cast walker [46]. Another trial that randomly assigned 48 patients to total contact casting or a removable cast walker (ie, Stabil-D) found no difference in the number of days to achieve healing (35 versus 39 days) [55].
Therapeutic shoes — After healing of the ulcer is achieved, prescriptive shoes with orthotic inserts are often prescribed to prevent recurrent ulceration [41]. In one trial, 400 patients with a history of foot ulcers were randomly assigned to wear therapeutic shoes or their usual footwear for two years [56]. The risk of re-ulceration was not found to be different between the groups. It should be noted, however, that this study consisted of, generally, relatively minor ulcers. Furthermore, over one-half of the patients did not have peripheral neuropathy. A subsequent study of prescriptive shoes with customized insoles based on pressure analysis showed a significant reduction in risk for re-ulceration [57,58].
Nonprescription rocker sole shoes (figure 3) may also offload the foot [59,60]. In a nonrandomized prospective study of 92 patients with healed diabetic foot ulcers, the first-year annual rate of foot ulcer relapse was significantly lower in patients who used stock diabetic shoes (rocker sole) compared with those who wore their usual footwear (15 versus 60 percent) [60]. In the United States, reimbursement from insurance carriers can be expected for one pair of shoes and three pairs of shoe inserts, provided the design of the shoe/insert meets qualifying guidelines.
Wedge shoes (eg, Darco International), also called half shoes, are available as forefoot and heel wedge shoes to offload the forefoot and heel, respectively (figure 4). These shoes may be useful under certain circumstances. For example, plantar heel ulcers are particularly difficult to heal because of an inability to adequately offload this region; the heel wedge shoe can be useful to achieve this goal.
The disadvantage of wedge shoes is that most patients, especially older adult patients or those with proprioception abnormalities, may not be able to maintain their balance, and some patients find walking in them difficult, if not impossible.
Knee walkers — Knee walkers are ambulatory assist devices that may be indicated for anyone with a lower extremity issue where weight bearing needs to be avoided (figure 5). These devices are becoming more popular in the treatment of diabetic ulcers as a means to offload the foot. There are no trials evaluating the effectiveness of knee walkers in healing diabetic foot ulcers.
MANAGING INFECTION —
The diagnosis of infection is clinical and is generally obvious when an ulcer contains purulent material, or there is redness, swelling, or warmth around the ulcer. Treatment is based on the clinical stages of infection [23]. Osteomyelitis is likely if bone can be seen on the floor of a deep ulcer or if it can be easily detected by probing the ulcer with a sterile, blunt stainless-steel probe (wound grade/stage: 2B, 3B). Radiologic tests may be useful if the diagnosis of osteomyelitis remains uncertain. (See "Diabetic foot infection, including osteomyelitis: Clinical manifestations and diagnosis".)
Tissue samples for culture and sensitivity should be obtained by wound curettage rather than wound swabs or irrigation because they provide more accurate results [61]. Ideally, tissue for culture should be obtained after debridement but prior to initiation of empiric antibiotic therapy. However, at times, this may not be practical. (See "Diabetic foot infection, including osteomyelitis: Clinical manifestations and diagnosis", section on 'Role of wound cultures' and "Diabetic foot infection, including osteomyelitis: Clinical manifestations and diagnosis", section on 'Diagnosis of underlying osteomyelitis'.)
The most common infecting organisms are aerobic gram-positive cocci. Other frequent pathogens are aerobic gram-negative bacilli and anaerobes, often as a second organism [23,62]. Empiric antimicrobial therapy should be selected based on the severity of the infection and the likelihood of resistant organisms (algorithm 2). (See "Diabetic foot infections, including osteomyelitis: Treatment".).
Subsequent antibiotic therapy should be tailored to the results of wound culture and susceptibility. It is not always necessary to cover all microorganisms isolated from cultures. The duration of treatment depends on the severity of infection and the presence of underlying or residual osteomyelitis. (See "Diabetic foot infections, including osteomyelitis: Treatment".)
ISCHEMIA AND REVASCULARIZATION —
Assessment of the adequacy of the circulation is an important component of the evaluation of all ulcers or postsurgical wounds, particularly those in patients with diabetes. Symptoms of claudication or extremity pain at rest and physical findings of diminished or absent pulses, cool temperature, pallor on elevation, or dependent rubor should raise suspicion about the presence of peripheral artery disease. (See "Lower extremity peripheral artery disease: Clinical features and diagnosis".)
Noninvasive vascular studies (ie, ankle-brachial index, toe waveforms, and pressures, pulse volume recordings) should be obtained to confirm the diagnosis. The ankle-brachial index is a measurement of the ratio of blood pressure at the ankle to that in the brachial artery that correlates with the presence and severity of arterial occlusive disease [63]. In patients with diabetes, the blood vessels may be incompressible, and ankle-brachial index values may be misleading. Segmental volume plethysmography and toe-brachial index values are more reliable for determining the severity of disease. The noninvasive diagnosis of lower extremity peripheral artery disease is reviewed in detail elsewhere. (See "Noninvasive diagnosis of upper and lower extremity arterial disease", section on 'Ankle-brachial index' and "Noninvasive diagnosis of upper and lower extremity arterial disease", section on 'Toe-brachial index'.)
Revascularization plays an important role in the management of diabetic foot ulcers in patients with documented peripheral artery disease (to avoid the need for amputation) [25]. When achievable, revascularization is associated with a lower incidence of amputation in patients with a diabetic foot ulcer and severe limb ischemia. As an example, in a longitudinal study of 564 patients, angioplasty or bypass grafting was performed in 75 and 21 percent, respectively [64]. Neither procedure was possible in the remaining 5 percent. The amputation rates were 8.2, 21.2, and 59.2 percent among patients who underwent angioplasty, bypass, or no revascularization.
SOCIETY GUIDELINE LINKS —
Links to society and government-sponsored guidelines from selected countries and regions around the world are provided separately. (See "Society guideline links: Diabetes mellitus in adults" and "Society guideline links: Open wound management".)
INFORMATION FOR PATIENTS —
UpToDate offers two types of patient education materials, "The Basics" and "Beyond the Basics." The Basics patient education pieces are written in plain language, at the 5th to 6th grade reading level, and they answer the four or five key questions a patient might have about a given condition. These articles are best for patients who want a general overview and who prefer short, easy-to-read materials. Beyond the Basics patient education pieces are longer, more sophisticated, and more detailed. These articles are written at the 10th to 12th grade reading level and are best for patients who want in-depth information and are comfortable with some medical jargon.
Here are the patient education articles that are relevant to this topic. We encourage you to print or e-mail these topics to your patients. (You can also locate patient education articles on a variety of subjects by searching on "patient info" and the keyword(s) of interest.)
●Beyond the Basics topics (see "Patient education: Type 1 diabetes: Overview (Beyond the Basics)" and "Patient education: Type 2 diabetes: Overview (Beyond the Basics)" and "Patient education: Foot care for people with diabetes (Beyond the Basics)")
SUMMARY AND RECOMMENDATIONS
●Patient assessment – The treatment of diabetic foot ulcers begins with a comprehensive assessment of the ulcer and the patient's overall medical condition. Evidence of underlying neuropathy, bony deformity, and peripheral artery disease should be actively sought. The ulcer is classified upon initial presentation, and with each follow-up visit, a standardized system is used to document the examination and treatment plan and to follow the progress of healing. (See 'Introduction' above and 'Ulcer classification' above.)
●Management – Adequate debridement, proper local wound care (debridement and dressings), redistribution of pressure on the ulcer by mechanical offloading, and control of infection and ischemia (when present) are important components of treatment for all ulcers, regardless of stage and depth. (See 'Management overview' above.)
●Local care – Local care includes sharp debridement and appropriate dressing management. When clinicians with expertise in sharp debridement are available, we prefer this method for debridement for diabetic foot wounds, as with other wounds requiring debridement. Wound care is based on the ulcer classification (algorithm 1). We use the wound, ischemia, and foot infection (WIfI) classification, which classifies the wound based on the presence and severity of the wound, infection, and ischemia (figure 1), and which can help set realistic expectations for healing and amputation risk (table 1). (See 'Local wound care' above and 'Managing infection' above.)
●Offloading – Several methods are available to achieve mechanical offloading. These include total contact casts, cast walkers, wedge shoes, and bed rest. The type of offloading that is used depends largely on local expertise. (See 'Mechanical offloading' above.)
●Revascularization – For patients who present with a diabetic foot ulcer and severe limb ischemia, we recommend early revascularization (Grade 1B). Revascularization should also be performed in patients with a nonhealing ulcer and any degree of limb ischemia. (See 'Allowable time course for primary healing' above and 'Ischemia and revascularization' above.)
●Preventing recurrence – Once a patient has healed an ulcer, they remain at very high risk for re-ulceration. Therefore, people with healed ulcers should be considered "in remission," a term that better communicates the lifetime of visits (often bimonthly) needed to reduce the risk of recurrence. The goals of long-term surveillance and care are to maximize ulcer-free, hospital-free, and activity-rich days. (See 'Follow-up care and ulcer prevention' above.)
ACKNOWLEDGMENT —
The UpToDate editorial staff acknowledges David K McCulloch, MD, who contributed to an earlier version of this topic review.