(A) Early perivascular lesion. (B) Neutrophils within and around blood vessels are characteristic. (C) Mature wedge-shaped lesion. (D) Advanced ulcerated lesion. Early lesions have a perivascular lymphoid infiltrate. Mature lesions have a wedge-shaped appearance. The most common type A lesions have large Reed-Sternberg-like cells and frequent mitoses in an inflammatory background. Type B lesions resemble mycosis fungoides (MF) and may be a papular variant of MF. Type C lesions demonstrate a relatively monotonous population of large CD30+ cells with few inflammatory cells.
Panel C reproduced from: Kadin ME. Primary cutaneous CD30-positive t-cell lymphoproliferative disorders. In: Hematopathology, Jaffe ES, Harris NL, Vardiman JW, et al. (Eds), Philadelphia, Elsevier 2011. Illustration used with the permission of Elsevier Inc. All rights reserved.
