Version July 2025
| Infectious diseases | Parasitic:
|
| Human immunodeficiency virus (HIV) infection | |
| Mycobacterium tuberculosis | |
| Cytomegalovirus | |
| Epstein-Barr virus | |
| Leprosy | |
| Candidiasis | |
| Atopic diseases | Allergic bronchopulmonary aspergillosis |
| Allergic fungal rhinosinusitis | |
| Atopic dermatitis | |
| Allergic asthma | |
| Allergic rhinitis | |
| Inborn errors of immunity | Hyperimmunoglobulin E syndrome (multiple mutations) |
| Wiskott-Aldrich syndrome | |
| Netherton disease | |
| Nezelof syndrome | |
| Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) | |
| Omenn syndrome | |
| Atypical complete DiGeorge syndrome | |
| Inflammatory diseases | Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) |
| Kawasaki disease | |
| Kimura disease | |
| Neoplasms | Hodgkin lymphoma |
| IgE myeloma | |
| Others | Tobacco smokers |
| Cystic fibrosis | |
| Nephrotic syndrome | |
| Bone marrow transplantation | |
| Graft-versus-host disease | |
| Bullous pemphigoid | |
| Drug effect | Aztreonam |
| Penicillin G |
IgE: immunoglobulin E.
* Allergic disease is the most common etiology of elevated IgE in resource-abundant countries, whereas parasitic infection is the most common cause in resource-limited countries.