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Patient education: Acute interstitial nephritis (The Basics)

Patient education: Acute interstitial nephritis (The Basics)

What is acute interstitial nephritis? — 

This is a rare condition that causes inflammation of the kidneys. Most of the time, it is caused by a reaction to certain medicines. These include medicines to treat pain, infections, and other conditions (table 1).

Diseases that involve the body's infection-fighting system (called "autoimmune diseases") and infections can also cause acute interstitial nephritis.

What are the symptoms of acute interstitial nephritis? — 

Some people have no symptoms. But symptoms can include:

●Nausea and vomiting

●Feeling very tired

●Rash – This can happen anywhere on the body.

●Cloudy or red urine

Are there tests for acute interstitial nephritis? — 

Yes. Tests include blood tests and urine tests.

Sometimes, a doctor might do a kidney "biopsy." For this test, the doctor takes a small sample of tissue from your kidney to look at under the microscope. Usually, the doctor gets the sample by inserting a needle straight through the skin in the back and into the kidney.

How is acute interstitial nephritis treated? — 

Most people get better after they stop the medicine that caused the condition. Some people also take steroid medicines, which help reduce inflammation.

Can acute interstitial nephritis be prevented? — 

Most people who take the medicines that can cause acute interstitial nephritis do not get it. But if you had acute interstitial nephritis in the past, you can reduce your chances of getting it again by avoiding the medicine that caused it the first time.

More on this topic

Patient education: Kidney biopsy (The Basics)

Patient education: Kidney (renal) biopsy (Beyond the Basics)

This topic retrieved from UpToDate on: May 11, 2025.
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