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Desloratadine: Drug information

Desloratadine: Drug information
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For additional information see "Desloratadine: Patient drug information" and "Desloratadine: Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: US
  • Clarinex
Pharmacologic Category
  • Histamine H1 Antagonist;
  • Histamine H1 Antagonist, Second Generation;
  • Piperidine Derivative
Dosing: Adult
Allergic rhinitis, perennial or seasonal

Allergic rhinitis, perennial or seasonal: Oral: 5 mg once daily.

Angioedema, acute allergic or recurrent idiopathic

Angioedema, acute allergic or recurrent idiopathic (off-label use):

Note: Not indicated for angioedema associated with anaphylaxis; use epinephrine if anaphylaxis symptoms are present (ie, risk of airway or cardiovascular compromise) (Ref).

Oral: 5 mg once or twice daily; may increase up to 10 mg twice daily (Ref).

Urticaria, new onset and chronic spontaneous

Urticaria, new onset (off-label use) and chronic spontaneous (labeled use):

New onset: Oral: Initial: 5 mg once daily. If symptom control is inadequate, may immediately increase to 5 mg twice daily (Ref).

Chronic spontaneous: Oral: Initial: 5 mg once daily. If symptom control is inadequate, may increase in 5 mg/day increments every 1 to 4 weeks up to 10 mg twice daily; periodically reevaluate necessity for continued treatment (Ref).

Urticaria, NSAID associated, prophylaxis

Urticaria, NSAID associated, prophylaxis (off-label use): Oral: 5 mg 30 minutes before intake of a strong COX-1 inhibitor (Ref).

Dosing: Kidney Impairment: Adult

Moderate to severe impairment: No dosage adjustment necessary; use with caution in severe impairment. Although the US manufacturer’s labeling recommends a dose reduction to 5 mg every other day in patients with mild to severe renal impairment, the increased exposure (Cmax and AUC) observed in single- and multiple-dose pharmacokinetic studies is not considered clinically relevant (Ref).

Hemodialysis: Poorly dialyzable: No dosage adjustment necessary; use with caution. Although the US manufacturer’s labeling recommends a dose reduction to 5 mg every other day in patients on dialysis, the increased exposure (Cmax and AUC) observed in single- and multiple-dose pharmacokinetic studies is not considered clinically relevant (Ref).

Dosing: Liver Impairment: Adult

No dosage adjustment necessary; use with caution in severe impairment. Although the US manufacturer’s labeling recommends a dose reduction to 5 mg every other day in patients with mild to severe hepatic impairment, the increased exposure (Cmax and AUC) observed in single- and multiple-dose pharmacokinetic studies is not considered clinically relevant (Ref).

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Desloratadine: Pediatric drug information")

Dosage guidance:

Dosage form information: In the US market, a dosage form may not be readily available to meet dosing needs in younger patients (ie, <6 years of age).

Allergic rhinitis, perennial

Allergic rhinitis, perennial:

Infants 6 to ≤11 months: Oral: 1 mg once daily.

Children ≤5 years: Oral: 1.25 mg once daily.

Children 6 to ≤11 years: Oral: 2.5 mg once daily.

Children ≥12 years and Adolescents: Oral: 5 mg once daily.

Allergic rhinitis, seasonal

Allergic rhinitis, seasonal:

Children 2 to ≤5 years: Oral: 1.25 mg once daily.

Children 6 to ≤11 years: Oral: 2.5 mg once daily.

Children ≥12 years and Adolescents: Oral: 5 mg once daily.

Urticaria, chronic idiopathic

Urticaria, chronic idiopathic:

Infants 6 to ≤11 months: Oral: 1 mg once daily.

Children ≤5 years: Oral: 1.25 mg once daily.

Children 6 to ≤11 years: Oral: 2.5 mg once daily.

Children ≥12 years and Adolescents: Oral: 5 mg once daily.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in manufacturer's labeling for pediatric patients (has not been studied); based on adult information, dosage adjustment may be necessary.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in manufacturer's labeling for pediatric patients (has not been studied); based on adult information, dosage adjustment may be necessary.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in children, adolescents, and adults unless otherwise indicated.

>10%:

Gastrointestinal: Diarrhea (infants and children: 15% to 20%)

Nervous system: Headache (14%), irritability (infants: 12%)

Respiratory: Cough (infants and children: 11%), upper respiratory tract infection (infants and children: 11% to 21%)

Miscellaneous: Fever (infants and children: 5% to 17%)

1% to 10%:

Dermatologic: Erythema of skin (infants: 3%), maculopapular rash (children: 3%)

Gastrointestinal: Anorexia (infants: 5%), dyspepsia (3%), increased appetite (children: 3%), nausea (infants, children, adolescents, and adults: 3% to 5%), vomiting (infants: 6%), xerostomia (3%)

Genitourinary: Urinary tract infection (children: 4%)

Infection: Parasitic infection (children: 3%), varicella zoster infection (children: 4%)

Nervous system: Dizziness (4%), drowsiness (infants: 9%), emotional lability (children: 3%), fatigue (2% to 5%), insomnia (infants: 5%)

Neuromuscular & skeletal: Myalgia (3%)

Respiratory: Bronchitis (infants: 6%), epistaxis (children: 3%), pharyngitis (infants, children, adolescents, and adults: 3% to 5%)

Postmarketing (any population):

Cardiovascular: Palpitations, tachycardia

Dermatologic: Pruritus, skin rash

Hepatic: Hepatitis, increased liver enzymes (including increased serum bilirubin)

Hypersensitivity: Hypersensitivity reaction (including anaphylaxis)

Nervous system: Movement disorder (including dystonia, extrapyramidal reaction, tic disorder), psychomotor agitation, seizure

Respiratory: Dyspnea

Contraindications

Hypersensitivity to desloratadine, loratadine, or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Hypersensitivity: Hypersensitivity reactions (including anaphylaxis) have been reported with use; discontinue therapy immediately with signs/symptoms of hypersensitivity.

Disease-related concerns:

• Hepatic impairment: Use with caution in patients with severe hepatic impairment.

• Renal impairment: Use with caution in patients with severe renal impairment.

Concurrent drug therapy issues:

• Sedatives: Effects may be potentiated when used with other sedative drugs or ethanol.

Special populations:

• Slow metabolizers: Use with caution in patients known to be slow metabolizers of desloratadine (incidence of side effects may be increased).

Dosage form specific issues:

• Phenylalanine: Some products may contain phenylalanine.

Warnings: Additional Pediatric Considerations

Desloratadine may increase susceptibility to seizures in pediatric patients, particularly in patients with a history of seizure disorders; 1 case series described 4 patients (ages: 5 to 16 years) who experienced seizures after initiation of desloratadine. Three of the 4 patients had known seizure disorders that were controlled prior to treatment with desloratadine. The final patient, who developed absence seizures after initiation of desloratadine, had a family history of febrile seizures but no personal history of seizure disorder (Cerminara 2013).

Safety and efficacy for the use of cough and cold products in pediatric patients <4 years of age are limited; the AAP warns against the use of these products for respiratory illnesses in young children. Serious adverse effects including death have been reported. Many of these products contain multiple active ingredients, increasing the risk of accidental overdose when used with other products. Health care providers are reminded to ask caregivers about the use of OTC cough and cold products in order to avoid exposure to multiple medications containing the same ingredient (AAP 2018; CDC 2007; FDA 2017; FDA 2018).

Some dosage forms may contain propylene glycol; in neonates, large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP 1997; Shehab 2009).

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Tablet, Oral:

Clarinex: 5 mg [contains corn starch, fd&c blue #2 (indigo carm) aluminum lake]

Clarinex: 5 mg [DSC] [contains fd&c blue #2 (indigo carm) aluminum lake]

Generic: 5 mg

Tablet Disintegrating, Oral:

Generic: 2.5 mg, 5 mg

Generic Equivalent Available: US

Yes

Pricing: US

Tablet, orally-disintegrating (Desloratadine Oral)

2.5 mg (per each): $5.83

5 mg (per each): $5.83

Tablets (Clarinex Oral)

5 mg (per each): $10.58

Tablets (Desloratadine Oral)

5 mg (per each): $5.02 - $8.69

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, Oral:

Generic: 5 mg

Administration: Adult

May be taken with or without food.

Orally disintegrating tablets should be placed on the tongue; tablet will disintegrate immediately. Take immediately after removing from blister package. Allow tablet to dissolve completely before swallowing. May be taken with or without water.

Administration: Pediatric

Oral: May administer without regard to food.

Orally dissolving tablet: Place orally dissolving tablet directly on the tongue; tablet will disintegrate immediately; may be taken with or without water. Take immediately after removing from blister package.

Use: Labeled Indications

Allergic rhinitis: Relief of nasal and non-nasal symptoms of seasonal (SAR) and perennial (PAR) allergic rhinitis

Urticaria, chronic spontaneous: Symptomatic relief of pruritus, reduction in number of hives, and reduction in size of hives associated with chronic spontaneous urticaria.

Use: Off-Label: Adult

Angioedema, acute allergic or recurrent idiopathic; Urticaria, new onset; Urticaria, nonsteroidal anti-inflammatory drug associated (prophylaxis)

Medication Safety Issues
Sound-alike/look-alike issues:

Clarinex may be confused with Celebrex

Metabolism/Transport Effects

Substrate of CYP2C8 (Major with inhibitors), CYP2C8 (Minor with inducers), P-glycoprotein (Minor); Note: Assignment of Major/Minor substrate status based on clinically relevant drug interaction potential;

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Amezinium: Antihistamines may increase stimulatory effects of Amezinium. Risk C: Monitor

Benzylpenicilloyl Polylysine: Coadministration of Antihistamines and Benzylpenicilloyl Polylysine may alter diagnostic results. Management: Suspend systemic H1 antagonists for benzylpenicilloyl-polylysine skin testing and delay testing until systemic antihistaminic effects have dissipated. A histamine skin test may be used to assess persistent antihistaminic effects. Risk D: Consider Therapy Modification

Betahistine: Antihistamines may decrease therapeutic effects of Betahistine. Betahistine may decrease therapeutic effects of Antihistamines. Risk C: Monitor

Cannabidiol: May increase serum concentration of CYP2C8 Substrates (High risk with Inhibitors). Risk C: Monitor

Certoparin: Antihistamines may increase therapeutic effects of Certoparin. Risk C: Monitor

CYP2C8 Inhibitors (Moderate): May increase serum concentration of Desloratadine. Risk C: Monitor

CYP2C8 Inhibitors (Strong): May increase serum concentration of Desloratadine. Risk C: Monitor

Haloperidol: QT-prolonging Agents (Indeterminate Risk - Caution) may increase QTc-prolonging effects of Haloperidol. Risk C: Monitor

Hyaluronidase: Antihistamines may decrease therapeutic effects of Hyaluronidase. Risk C: Monitor

Lumacaftor and Ivacaftor: May decrease serum concentration of CYP2C8 Substrates (High Risk with Inhibitors or Inducers). Lumacaftor and Ivacaftor may increase serum concentration of CYP2C8 Substrates (High Risk with Inhibitors or Inducers). Risk C: Monitor

Pitolisant: Antihistamines may decrease therapeutic effects of Pitolisant. Risk X: Avoid

QT-prolonging Agents (Highest Risk): QT-prolonging Agents (Indeterminate Risk - Caution) may increase QTc-prolonging effects of QT-prolonging Agents (Highest Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Food Interactions

Food does not affect bioavailability.

Pregnancy Considerations

Outcome data following maternal use of desloratadine during pregnancy are available (Andersson 2020, Layton 2009). Based on the limitations of available data, second-generation antihistamines are considered acceptable for use during pregnancy, with preference given to agents with more study (EAACI [Zuberbier 2022]).

Algorithms are available for the treatment of acute rhinitis and urticaria. When treatment with a second-generation oral antihistamine is recommended, agents other than desloratadine may be preferred for use during pregnancy (AAAAI/ACAAI [Dykewicz 2020], EAACI [Zuberbier 2022]).

Breastfeeding Considerations

Desloratadine is present in breast milk.

Desloratadine is the primary metabolite of Loratadine. Desloratadine is present in breast milk following maternal administration of loratadine (Hilbert 1988); refer to the loratadine monograph for additional information.

Drowsiness and irritability have been reported in breastfed infants exposed to antihistamines (Ito 1993). In general, second-generation antihistamines are less sedating as compared to their first-generation counterparts. Infants exposed to a second-generation antihistamine via breast milk should be monitored for irritability, jitteriness, or drowsiness (Butler 2014).

According to the manufacturer, the decision to continue or discontinue breastfeeding during therapy should consider the risk of exposure to the infant and the benefits of treatment to the mother. Use of a second-generation antihistamine is preferred when an oral antihistamine is needed in lactating patients (Butler 2014, EAACI [Zuberbier 2022]).

Dietary Considerations

Some products may contain phenylalanine.

Mechanism of Action

Desloratadine, a major active metabolite of loratadine, is a long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity.

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: Within 1 hour.

Duration: 24 hours.

Distribution: Vd: ~49 L/kg (Devillier 2008).

Protein binding: Desloratadine: 82% to 87%; 3-hydroxydesloratadine (active metabolite): 85% to 89%.

Metabolism: Hepatic to active metabolite, 3-hydroxydesloratadine (specific enzymes not identified); subsequently undergoes glucuronidation. Decreased in slow metabolizers of desloratadine.

Half-life elimination:

Children 2 to 5 years: Mean: 16.4 hours (Gupta 2007).

Children 6 to 11 years: Mean: 19.4 hours (Gupta 2007).

Adults: ~27 hours.

Time to peak:

Children 2 to 5 years: Mean: 3.17 hours (range: 1.5 to 8 hours) (Gupta 2007).

Children 6 to 11 years: Mean: 3.57 hours (range: 4 to 12 hours) (Gupta 2007).

Adults: ~3 hours.

Excretion: Urine (41% of radioactive dose); feces (47% of radioactive dose) (Devillier 2008).

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Altered kidney function: AUC and Cmax are increased.

Hepatic function impairment: AUC and half-life are increased.

Pediatric: Systemic exposure in children (based on AUC and Cmax) is similar to adults (Gupta 2007).

Older adult: Cmax and AUC are 20% higher. The half-life is 33.7 hours.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Actilor | Aeriallerg | Aerius | Batlor | Delohist | Deslarex | Desloxan | Destalife | Dora | Glendes | Hisdine | Lorius;
  • (AR) Argentina: Aerius | Azomyr | Delorat | Desaler | Deslo | Desloramar | Desloratadina richet | Frenaler | Hexaler | Novo Alerpriv | Predualergin | Sinaler | Teralmina;
  • (AT) Austria: Aerius | Dasselta | Desloraderm | Desloratadin | Desloratadin actavis | Desloratadin aristo | Desloratadin Genericon | Desloratadin Pluspharma | Desloratadin ratiopharm | Desloratadin Sandoz | Desloratadin stada | Desloratadine ratiopharm;
  • (AU) Australia: Apohealth desloratadine | Blooms the chemist desloratadine | Claramax | Desonex | Priceline pharmacy hayfever & allergy relief;
  • (BD) Bangladesh: Adlorin | Aloran | Aslor | Clarex | Deen | Delorin | Delosia | Delot | Delotad | Derat | Des | Desatrol | Deslona | Deslor | Deslorin | Deslosil | Desmark | Desmin | Desodin | Desolet | Desotem | Destacin | Destin | Dora | Isodin | Momento | Neocilor | Orinex | Relergy | Sarinex | Sedno;
  • (BE) Belgium: Aerius | Desloratadin Sandoz | Desloratadine ab | Desloratadine actavis | Desloratadine Apotex | Desloratadine EG | Desloratadine krka | Desloratadine Teva;
  • (BF) Burkina Faso: Aerius | D lor | Deslatyne | Deslor | Deslora denk | Erlus | Rodera;
  • (BG) Bulgaria: Aerius | Desloratadin Zentiva | Desloratadine alvogen | Desloratadine ratiopharm | Desloratadine sopharma | Desybel | Flynise | Jovesto | Lordestin;
  • (BR) Brazil: Aleradina | Aloff | Aloff xpe | Aviant | Desalex | Deslin | Deslorana | Desloratadina | Destadin | Esalerg | Histabloc | Leg | Leg odt | Sigmaliv;
  • (CH) Switzerland: Aerius | Desloratadin actavis | Desloratadin axapharm | Desloratadin helvepharm | Desloratadin Mepha | Desloratadin Sandoz | Desloratadin spirig hc | Poll x;
  • (CI) Côte d'Ivoire: Aerius | Akerol | Allergus | Delevon | Deller | Deslogen | Desloratadine generis | Desloratadine sp | Doxafin | Dyldes | Erlus | Histadius;
  • (CL) Chile: Aerius | D histaplus | Desinaler | Desloratadina | Despeval | Despex | Lotadin | Mailen | Neo alledryl | Neoclaritine | Neohysticlar | Rinofilax | Tamides;
  • (CN) China: Aerius | Bei xue | Di heng sai | Fu bi ding | Xin min ting;
  • (CO) Colombia: Aerius | Alergus | Alertinol | Amerotadina | Cristhaler | Desalex | Desinista | Deslair | Desler | Deslodex | Desloran | Desloratadina | Desloratadina Genfar | Desloratadina La Sante | Desloratadina mk | Desloratamin | Deslorina | Deslosher | Deslotin | Desloweid | Deslox | Desna | Dexio | Expodes | Ezcloren d | Flaxerd | Globistamin d | Histair | Histaline | Impodina | Inuxgen | Isticol | Lopidex | Lorad | Mailen | Neohysticlar | Newtarpan | Oxiclarine | Prilex | Renilax | Respimar | Riniloran | Rinotadin | Sidres | Sin alergyn | Sinalergyn | Sinnaller | Sinuxgen | Zeraller;
  • (CR) Costa Rica: Aerius | Aeroviant | Deslora denk | Desloratadina | Desloratadina mk | Deslorateg | Mailen | Neohystaclar | Novo Alerpriv | Sensidex;
  • (CZ) Czech Republic: Aerius | Azomyr | Daslodil | Dasmini | Dasselta | Delesit | Desloratadin +pharma | Desloratadin apotex | Desloratadin aurovitas | Desloratadin krka | Desloratadin labormed | Desloratadin mylan | Desloratadin stada | Desloratadin viatris | Desloratadin xantis | Desloratadin Zentiva | Desloratadine actavis | Desloratadine glenmark | Desloratadine Teva | Geslora | Jovesto | Lotera;
  • (DE) Germany: Aerius | Dasselta | Deslopuren | Deslora 1 a pharma | Deslora denk | Desloraderm | Desloradia | Desloranio | Desloratadin | Desloratadin 1 a pharma | Desloratadin actavis | Desloratadin adgc | Desloratadin AL | Desloratadin aristo | Desloratadin axunio | Desloratadin glenmark | Desloratadin heumann | Desloratadin Hexal | Desloratadin hormosan | Desloratadin puren | Desloratadin ratiopharm | Desloratadin stada | Desloratadine ratiopharm | Lorano pro;
  • (DK) Denmark: Deslor | Desloratadin accord | Desloratadin glenmark | Desloratadine 1a farma | Desloratadine arrow | Flynise | Irinospen | Jovesto;
  • (DO) Dominican Republic: Aerius | Alerpred | Desarius | Desloratadina | Desloratadina calox | Desloratadina Sandoz | Despeval | Dexio | Esparflin | Lestacan | Lorax | Maxaire | Novo Alerpriv | Ubrile;
  • (EC) Ecuador: Aeridin | Alertan | Aviant | Azomyr | D histaplus | Delorat | Desler | Desloran | Desloratadina | Desloratadina La Sante | Desloratadina mk | Despex | Dexio | Hexaler | Mailen | Neohysticlar | Neolarmax | Rinofilax | Sensidex;
  • (EE) Estonia: Aerius | Dasergin | Dasselta | Desloratadine sandoz | Desloratadine Zentiva | Yosqiero;
  • (EG) Egypt: Aerius | Alergaway | Allergaway | Delarex | Delora stop | Desa | Deslorastamine | Deslorat | Deslorex | Embanodex | Endstamine | Fernilar | Hygi-tadine | Lorafast | Nouvonase | Stimloric | Tendratine;
  • (ES) Spain: Aerius | Azomyr | Dasselta | Desloratadina | Desloratadina actavis | Desloratadina almus | Desloratadina alter | Desloratadina apotex | Desloratadina apotex ag | Desloratadina Aristo | Desloratadina aurobindo | Desloratadina aurovitas | Desloratadina Cinfa | Desloratadina cinfamed | Desloratadina combix | Desloratadina edigen | Desloratadina flas combix | Desloratadina gedeon richter | Desloratadina geprem | Desloratadina Kern | Desloratadina Kern Pharma | Desloratadina krka | Desloratadina lupin | Desloratadina mabo | Desloratadina Mylan | Desloratadina normon | Desloratadina pensa | Desloratadina pharmagenus | Desloratadina Pharmakern | Desloratadina Qualigen | Desloratadina ranbaxy | Desloratadina Sandoz | Desloratadina stada | Desloratadina tarbis | Desloratadina Tecnigen | Desloratadina teva | Desloratadina viatris | Desloratadina vir;
  • (ET) Ethiopia: Aria des | Deslora denk | Deslorat | Desrinal | Destacure | Eslotin;
  • (FI) Finland: Aerius | Caredin | Dasselta | Desloratadin mylan | Desloratadin orion | Desloratadin stada | Desloratadine actavis | Desloratadine ratiopharm | Desloratadine Teva | Deslox | Destamin | Flynise | Kevenix;
  • (FR) France: Aerius | Dasselta | Desloratadine accord | Desloratadine actavis | Desloratadine almus | Desloratadine arrow | Desloratadine biogaran | Desloratadine Cristers | Desloratadine EG | Desloratadine evolugen | Desloratadine GNR | Desloratadine krka | Desloratadine mylan | Desloratadine phr | Desloratadine Ranbaxy | Desloratadine sandoz | Desloratadine Teva | Desloratadine vj pharm | Desloratadine Zentiva;
  • (GB) United Kingdom: Desloratadine Teva | Irinospen | Neoclarityn;
  • (GR) Greece: Aerius | Desloratadine/Sandoz | Desloratadine/target | Neoclarityn | Pylodes | Rhinohelp | Rinispes;
  • (HK) Hong Kong: Aerius | Allora | Deslorin | Destavell | Lorastad d | Lotarius;
  • (HR) Croatia: Aerius | Alerdin | Dasselta | Desloratadin actavis | Desloratadine Teva | Deslordis | Escontral;
  • (HU) Hungary: Aerius | Alvotadin | Azomyr | Desaero | Desloratadin actavis | Desloratadine actavis | Desloratadine mylan | Desloratadine ratiopharm | Desloratadine Stada | Desloratadine Teva | Deslorep | Esradin | Flynise | Inaller | Lordestin | Lordestin akut;
  • (ID) Indonesia: Aerius | Aleros | Desdin | Deslotine | Destavell | Eslor;
  • (IE) Ireland: Dasselta | Deslor | Efestad | Neoclarityn;
  • (IL) Israel: Aerius;
  • (IN) India: Alenix | Alerdain | Alerta d | Allerde | Arolor | D alert | D lorinol | D luracise | D-loratin | Dazit | De argella | Delorta | Deltar | Des-od | Desent | Deslor | Deslotag | Desnova | Desobit | Desogold | Deswin | Dexly | Dezlin | Dezlorid | Disitch | Dyl | Dyl d | Eslot | Isolor | Lorava | Lorday | Loreta | Nelora | Neoloridin | Nucope | Otrivin-alert | Rodera | Sylor | Tastylora | Winal;
  • (IQ) Iraq: Awadelor | Desloradain | Deslorasam | Deslorid | Dislorasam | Larius;
  • (IS) Iceland: Aerius | Azomyr | Desloratadine actavis | Flynise;
  • (IT) Italy: Aerius | Aremas | Azomyr | Dasselta | Desloratadina | Desloratadina actavis | Desloratadina aurobindo | Desloratadina doc generici | Desloratadina EG | Desloratadina mylan pharma | Desloratadina pensa | Desloratadina ratiopharm | Desloratadina Sandoz | Desloratadina Zentiva | Efestad;
  • (JO) Jordan: Aeriallerg | Aerius | Ales | Deslora | Dislara | Histacare | Lorius | Noura;
  • (JP) Japan: Desalex;
  • (KE) Kenya: Aerius | D lor | D lorat | Dazit | Delora | Desafe | Deselex | Deslatyne | Deslora denk | Deslorin | Deslot | Desodin | Desostar | Doxafin | Larinex | Momento | Neocilor | Neolor;
  • (KR) Korea, Republic of: Aerius;
  • (KW) Kuwait: Actilor | Aerius | Iris;
  • (LB) Lebanon: Aeriallerg | Aerius | Dareq | Deline | Deslor | Desloratadine arrow | Desloratadine normon | Eslorat | Oradus | Rina;
  • (LI) Liechtenstein: Aerius | Desloratadine actavis;
  • (LT) Lithuania: Aerius | Dasselta | Desloratadina Kern Pharma | Desloratadine Rph | Desloratadine sopharma | Kevenix | Rodispes | Veromon;
  • (LU) Luxembourg: Aerius | Desloratadin Sandoz | Desloratadine EG;
  • (LV) Latvia: Aerius | Dasselta | Desloratadine actavis | Desloratadine aurovitas | Desloratadine sopharma;
  • (MA) Morocco: Aerius | Destec | Desyal | Ergic | Erlus | Lodes | Loreus | Naureus;
  • (MT) Malta: Deslor;
  • (MX) Mexico: Abrunt | Aviant | Azomyr | Bennet | Blotamin | Degortrina | Deslibal | Desloratadina | Desloratadina landsteiner | Gronase | Histapharm | Kajuva | Liberdux | Lideater | Lirudine | Selectaler | Sensidex | Tadocil | Urtisin lam | Valgab;
  • (MY) Malaysia: Aerius | Ajalorin | Avorius | Caridine | Dasselta | Desloratadine sandoz | Deslova | Destacure | Dezal | Glendes | Sedno | Synerrv desloratadine | Xynoz;
  • (NG) Nigeria: Delora stop | Hayvent | Mairex | Momento;
  • (NL) Netherlands: Aerius | Dasselta | Desloracell | Desloratadine 2,5 mg focus | Desloratadine accord | Desloratadine adoh | Desloratadine aurobindo | Desloratadine ratiopharm | Desloratadine Teva | Neoclarityn;
  • (NO) Norway: Aerius | Azomyr | Caredin | Desloratadin glenmark | Desloratadine actavis | Flynise;
  • (NZ) New Zealand: Claramax | Hayfever & allergy | Hayfever & allergy relief;
  • (PA) Panama: Aerius | Desarius | Deslodex | Deslora denk | Desloratadina | Mailen | Sensidex;
  • (PE) Peru: Aeridin | Aerius | Aviant | D'Ventil | Desloglob | Deslorafen | Desloramina | Desloran | Deslorat | Desloratadina | Deslortin | Deslova | Frenaler | Letizia | Lomed | Loralergan | Nafolix | Neoclarityne | Neolarmax | New lorat | Rinodual | Rinofilax | Ryna del | Vitallerg;
  • (PH) Philippines: Aerius | Allergon | Aroled | Deslo | Deslodine | Deslogen | Deslorastal | Genodes | Neo loridin | Sarinex;
  • (PK) Pakistan: Agenor | Alenor | Alldes | Aloran | Aloret | Altadine | Antimin d | Arozid | D lor | D next | Delergic | Dellerge | Delomat | Delorta | Delorvin | Delot | Deltafast | Des loratlax | Des-od | Desatil | Desbro | Descover | Desdine | Desgen | Deslet | Deslin | Deslo | Deslofn | Deslorat | Deslort | Deslotin | Deslozam | Deslozon | Desmed | Desnova | Deso l | Desora | Desotin | Destazine | Destidine | Destina | Detora | Dexio | Dictrin | Dinestin | Dingo | Disdine | Distamin | Doara | Dyl | Eslod | Eslor | Genelor | Histanil D | Jardin d | Kadisdin | Larinex | Lewdes | Lorades | Mdisin | Neo antial | Neolor | Neulorax | Retoret | Selora | Softin od | Weltol;
  • (PL) Poland: Aerius | Alerdes | Alergo max | AlergoTeva | Aleric deslo | Aleric deslo active | Aleric deslo pro | Azomyr | Clarderin | Dasergin | Dasselta | Dehistar | Delortan | Delortan allergy | Desada | Deslodyna | Desloratadine +pharma | Desloratadine actavis | Desloratadine aurovitas | Desloratadine dr.max | Desloratadine genoptim | Desloratadine mylan | Desloratadyna apotex | Dynid | Dynid gem | Flynise | Goldesin | Goldesin alerstop | Hitaxa | Hitaxa fast | Jovesto | Pylodes | Suprodeslon | Symdes | Teslor;
  • (PR) Puerto Rico: Clarinex;
  • (PT) Portugal: Aerius | Azomyr | Desloratadina actavis | Desloratadina alter | Desloratadina alvogen | Desloratadina Aristo | Desloratadina aurobindo | Desloratadina aurovitas | Desloratadina azevedos | Desloratadina Basi | Desloratadina Bluepharma | Desloratadina ciclum | Desloratadina Cinfa | Desloratadina farmoz | Desloratadina Genepharm | Desloratadina generis | Desloratadina germed | Desloratadina goibela | Desloratadina krka | Desloratadina labesfal | Desloratadina labormed | Desloratadina lupin | Desloratadina mepha | Desloratadina Mylan | Desloratadina ratiopharm | Desloratadina teva | Desloratadina tolife;
  • (PY) Paraguay: Alergicap | Desloradex | Despeval | Despex | Lomed | Loner | Mailen | Megadesaler fb | Neo alledryl | Recardex | Supraler;
  • (QA) Qatar: Aeriallerg | Aerius | Deslarex | Desloratadine/Genepharm | Desloren | Desrinal | Dislara | Glendes | Histacare | Iris | Lorius | Rina;
  • (RO) Romania: Aerius | Dasselta | Desloratadina actavis | Desloratadina alvogen | Desloratadina amring | Desloratadina aurobindo | Desloratadina labormed | Desloratadina Sandoz | Desloratadina terapia | Desloratadina teva | Dynid | Lordestin;
  • (RU) Russian Federation: Aerius | Blogir 3 | Delorsin | Desal | Desloratadin | Desloratadine canon | Desloratadine Teva | Desloratadine vertex | Elizey | Eslontin | Ezlor | Lazamirt | Lordestin | Nalorius;
  • (SA) Saudi Arabia: Aeriallerg | Aerius | Batlor | Celer | Deslin | Deslor | Desloratadine glenmark | Destamin | Dorius | Iris | Loradeel | Loradin | Loreta | Lorinex | Neorin | Rina;
  • (SE) Sweden: Aerius | Caredin | Dasselta | Desloratadin ABECE | Desloratadin accord | Desloratadin Apofri | Desloratadin bijon | Desloratadin ebb | Desloratadin mylan | Desloratadin stada | Desloratadin viatris | Desloratadine actavis | Desloratadine glenmark | Desloratadine ratiopharm | Desloratadine sandoz | Desloratadine Teva | Flynise;
  • (SG) Singapore: Aerius | Alrinast | Desalex | Desloratadine sandoz;
  • (SI) Slovenia: Aerius | Dasselta | Dasselta control | Desloratadin ratiopharm | Esradin | Lentrica;
  • (SK) Slovakia: Aerius | Azomyr | Dasselta | Dasseltino | Delesit | Deslomed | Desloratadin saneca | Desloratadin Zentiva | Desloratadine actavis | Desloratadine glenmark | Geslora | Jovesto | Lordestin | Lotera | Spirabel;
  • (SR) Suriname: Desloratadine mylan;
  • (TH) Thailand: Aerius | Desloratadine sandoz | Lorius;
  • (TN) Tunisia: Aerius | Allergus | Clarius | Deslor | Desloryne | Histam | Lorinex;
  • (TR) Turkey: Aerius | Alores | Alrinast | Aria des | Deloday | Deslodin | Desloran | Desrinal | Dicomex | Doranit | Doxafin | Eslotin | Lordes;
  • (TW) Taiwan: Denosin | Desdin | Desora;
  • (UA) Ukraine: Aerius | Alerdes | Alernova | Alersis | Allergomax | Allergostop | Astria | Blogir 3 | Desloratadine astrapharm | Desorus | Dezradin | Edem | Elehius | Elizium | Eridez | Eridez darnitsa | Eslotin | Fri al | Fribris | Hitaxa | Loratek | Lordes;
  • (UG) Uganda: Aeriallerg | Aerius | Alrinast | Delohist | Deslora denk | Deslorat | Deslozed | Eslotin | Iris | Larinex | Lorfact d | Neo loridin;
  • (UY) Uruguay: Aerius | Cripan | Delorat | Desloratadina Icu Vita | Desloratadina teva | Dislen | Mailen | Mailen rapid;
  • (VE) Venezuela, Bolivarian Republic of: Aerius | Agertrax | Bio Desloratadine | Desalex | Desler | Deslorat | Desloratadina | Deslorin | Deslort | Esparflin | Gamorvan | Histaler | Liberdux | Ofanex | Ventus;
  • (VN) Viet Nam: Adesvadin | Aleradin | Audocals | Bostanex | Bvpalin | Desbebe | Descallerg | Desdinta | Dessubaby | Elarothene | Eurodora | Ladexnin | Lorastad d | Ruradin | Savoze | Sosallergy | Tadaritin | Tanadeslor | Usdeslor;
  • (ZA) South Africa: Acuhist | Adco desloratadine | Aerius | Aerzit | Arydese | Clarex | Dazit | Desaway | Deselex | Deseneeze | Desodene | Desotab | Loralex | Neoclarityne | Neoloridin | Pollentyme nd;
  • (ZM) Zambia: Aerius | D lor | Rodera
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