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Atypical mole syndrome

Atypical mole syndrome
Syndrome name Clinical features
Sporadic syndromes
Atypical mole syndrome Three or more of the following characteristics:
  1. Two or more clinically atypical nevi
  2. >100 nevi >2 mm diameter or >50 nevi if <20 or >50 years of age
  3. Nevi abnormally distributed (buttocks or dorsum of foot)
  4. Nevi in the anterior scalp
  5. Iris pigmented lesion(s)
Classical atypical mole syndrome
  1. >100 melanocytic nevi
  2. One or more nevi >8 mm diameter
  3. One or more nevi with atypical features
B-K mole ≥10 mm diameter; irregular outline; haphazard mixture of tan, brown, black, and pink; small, palpable, dermal component
B-K mole syndrome Fewer than 10 B-K moles to more than 100 moles prominent on the upper trunk and extremities; variability of mole size (5 to 15 mm diameter), outline, and color
Familial syndromes
Familial atypical mole syndrome
  1. Two or more family members with atypical moles
  2. One or more family members with melanoma
Familial atypical multiple mole melanoma syndrome
  1. Melanoma in 2 or more first- or second-degree relatives
  2. Many atypical nevi (often more than 50)
Reproduced from: Marghoob AA, Kovalyshyn I, Halpern AC. Management of Dysplastic Nevi and Melonomas. In: Surgery of the Skin, 2nd ed, Robinson JK (Ed), Elsevier 2010. Table used with the permission of Elsevier Inc. All rights reserved.
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