General eligibility criteria for allogeneic hematopoietic cell transplantation (allo-HCT)

Disease-related indication

Suitable donor available

Karnofsky performance status ≥70 for a myeloablative HCT or ≥50 for a nonmyeloablative HCT

Kidney function:

While no specific cutoff is universally used, many centers limit allo-HCT to those with a serum creatinine <2 mg/dL (177 micromol/L) or CrCl >50

Cardiac reserve:

LVEF >35

Pulmonary function:

A corrected DLCO >35%

Liver function:

No frank cirrhosis of the liver

Adequate psychosocial and financial support

While no specific age cutoff is universally used, many centers limit myeloablative allo-HCT to patients <55 years and reduced intensity allo-HCT to patients <75 years

CrCl: creatinine clearance; DLCO: diffusing capacity of the lungs for carbon monoxide; LVEF: left ventricular ejection fraction.

Graphic 88755 Version 3.0

خرید پکیج

General eligibility criteria for allogeneic hematopoietic cell transplantation (allo-HCT)