General eligibility criteria for allogeneic hematopoietic cell transplantation (allo-HCT)

Disease-related indication

Suitable donor available

Karnofsky performance status ≥70 for a myeloablative HCT or ≥50 for a nonmyeloablative HCT

Renal function:

While no specific cutoff is universally used, many centers limit allo-HCT to those with a serum creatinine <2 mg/dL (177 micromol/L) or CrCl >50

Cardiac reserve:

LVEF >35

Pulmonary function:

A corrected DLCO >35 percent

Liver function:

No frank cirrhosis of the liver

Adequate psychosocial and financial support

While no specific age cutoff is universally used, many centers limit myeloablative allo-HCT to patients <55 years and reduced intensity allo-HCT to patients <75 years

LVEF: left ventricular ejection fraction; DLCO: diffusing capacity of the lungs for carbon monoxide.

Graphic 88755 Version 2.0

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General eligibility criteria for allogeneic hematopoietic cell transplantation (allo-HCT)