Thrombophilia | Laboratory studies* |
Factor V Leiden mutation | DNA-based PCR assay (or screen with functional assay for activated protein C resistance) |
Prothrombin 20210 mutation | DNA-based PCR assay |
Antithrombin deficiency | Antithrombin activity via chromogenic or clotting assay |
Protein C deficiency | Protein C activity via chromogenic or clotting assay |
Protein S deficiency | Free and total protein S levels measured via immunoassays |
Antiphospholipid antibodies¶ | Immunoassays for IgG and IgM antibodies to cardiolipin and beta-2-glycoprotein-I and functional assay for the lupus anticoagulant phenomenon |
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