Factors that can influence results of thrombophilia testing in children and adolescents

Condition	Abnormalities that may result
Acute thrombosis	Decreased protein C activity Low protein S level Decreased antithrombin activity
Asparaginase therapy (eg, for acute lymphoblastic leukemia)	Decreased antithrombin activity
Cyanotic congenital heart disease	Decreased protein C activity Low protein S level Decreased antithrombin activity
Estrogen-containing contraception	Low protein S level
Heparin therapy	Decreased antithrombin activity
Infection	Transient antiphospholipid antibodies
Inflammation	Low protein S level
Liver disease	Decreased protein C activity Low protein S level Decreased antithrombin activity
Nephrotic syndrome	Decreased protein C activity Low protein S level
Pregnancy	Low protein S level
Sickle cell disease	Decreased protein C activity Low protein S level Levels decrease further during acute vaso-occlusive episodes
Vitamin K deficiency	Decreased protein C activity Low protein S level
Warfarin therapy	Decreased protein C activity Low protein S level

This table summarizes factors that can influence results of non-DNA-based thrombophilia testing (including proteins C and S, and antithrombin levels). Thrombophilia testing is best performed after recovery from the acute venous thromboembolism to avoid an incorrect diagnosis. Any abnormal non-DNA-based test result should be confirmed with repeat testing. DNA-based tests for factor V Leiden mutation and prothrombin G20210A mutation are not affected by any of the conditions listed in this table and they need not be repeated. Refer to UpToDate's topic on thrombophilia testing for additional details.

Graphic 88805 Version 6.0

خرید پکیج

Factors that can influence results of thrombophilia testing in children and adolescents