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Gadobenate dimeglumine: Drug information

Gadobenate dimeglumine: Drug information
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For additional information see "Gadobenate dimeglumine: Patient drug information" and "Gadobenate dimeglumine: Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
ALERT: US Boxed Warning
Risk associated with intrathecal use:

Intrathecal administration of gadolinium-based contrast agents (GBCAs) can cause serious adverse reactions including death, coma, encephalopathy, and seizures. Gadobenate dimeglumine is not approved for intrathecal use.

Nephrogenic systemic fibrosis:

GBCAs increase the risk for nephrogenic systemic fibrosis (NSF) among patients with impaired elimination of the drugs. Avoid use of gadobenate dimeglumine in these patients unless the diagnostic information is essential and not available with noncontrasted magnetic resonance imaging (MRI) or other modalities. NSF may result in fatal or debilitating systemic fibrosis affecting the skin, muscle, and internal organs.

The risk of NSF appears highest among patients with chronic, severe kidney disease (glomerular filtration rate [GFR] <30 mL/minute/1.73 m2) or acute kidney injury.

Screen patients for acute kidney injury and other conditions that may reduce renal function. For patients at risk for chronically reduced renal function (eg, >60 years, hypertension, diabetes), estimate the GFR through laboratory testing.

For patients at highest risk of NSF, do not exceed the recommended gadobenate dimeglumine dose and allow a sufficient period of time for elimination of the drug from the body prior to readministration.

Brand Names: US
  • MultiHance
Brand Names: Canada
  • MultiHance
Pharmacologic Category
  • Diagnostic Agent;
  • Gadolinium-Containing Contrast Agent;
  • Linear Gadolinium-Based Contrast Agent;
  • Radiological/Contrast Media (Ionic, High Osmolality);
  • Radiological/Contrast Media, Paramagnetic Agent
Dosing: Adult
CNS imaging

CNS imaging: IV: 0.1 mmol/kg (0.2 mL/kg).

Renal and aorto-ilio-femoral vasculature imaging

Renal and aorto-ilio-femoral vasculature imaging: IV: 0.1 mmol/kg (0.2 mL/kg); calculate scan delay with test bolus (1 to 2 mL) or with automatic detection technique.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling; use with caution. Risk for NSF development increases as renal function decreases.

Hemodialysis: If administered to patients already receiving hemodialysis, consider prompt hemodialysis following exposure (eg, within 3 hours) (Ref). Data has shown hemodialysis enhances gadolinium elimination with average gadolinium excretory rates of 78%, 96%, and 99% in the first, second, and third hemodialysis sessions, respectively (Ref).

Peritoneal dialysis: Likely to be less efficient at clearing gadolinium (Ref). If unable to perform hemodialysis after the procedure, more frequent peritoneal dialysis cycles are suggested (Ref).

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Gadobenate dimeglumine: Pediatric drug information")

Note: Dosing presented in mL/kg and mmol/kg; use caution.

CNS MRI

CNS MRI:

Infants and Children <2 years of age: IV: 0.1 to 0.2 mL/kg (0.05 to 0.1 mmol/kg); may begin imaging immediately after administration.

Children ≥2 years and Adolescents: IV: 0.2 mL/kg (0.1 mmol/kg); may begin imaging immediately after administration.

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; acute kidney injury requiring dialysis has been reported with contrast agent use in patients with chronic renal dysfunction; risk may be increased with higher doses of contrast agent; use with caution. Risk for nephrogenic systemic fibrosis (NSF) development increases as renal function decreases.

Dialysis: There are no pediatric-specific recommendations; based on experience in adult patients, the following has been observed:

Hemodialysis: If administered to patients already receiving hemodialysis, consider prompt hemodialysis following exposure (eg, within 3 hours) (Ref). Data has shown hemodialysis enhances gadolinium elimination with average gadolinium excretory rates of 78%, 96%, and 99% in the first, second, and third hemodialysis sessions, respectively (Ref).

Peritoneal dialysis: Likely to be less efficient at clearing gadolinium (Ref). If unable to perform hemodialysis after the procedure, more frequent peritoneal dialysis cycles are suggested (Ref).

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. In adults with hepatic impairment (Child Pugh class B or C), pharmacokinetics were not significantly altered.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in adults unless otherwise noted.

1% to 10%:

Gastrointestinal: Nausea (1%), vomiting (neonates, infants, children, adolescents, adults: ≤1%)

Local: Injection-site reaction (1%)

Nervous system: Feeling hot (1%), headache (1%)

<1%:

Cardiovascular: Altered blood pressure, chest discomfort, chest pain, ECG abnormality (including PR, QRS, QT, ST segment changes on ECG), first-degree atrioventricular block

Dermatologic: Hyperhidrosis (neonates, infants, children, adolescents, adults), pruritus, skin rash, urticaria

Gastrointestinal: Abdominal distress, abdominal pain, diarrhea, dysgeusia, necrotizing pancreatitis (acute), oral paresthesia, xerostomia

Hematologic & oncologic: Basophilia

Hypersensitivity: Facial swelling, hypersensitivity reaction, nonimmune anaphylaxis, swelling of lips, tongue edema

Nervous system: Altered sense of smell, chills, dizziness, malaise, paresthesia, seizure, tremor

Neuromuscular & skeletal: Laryngospasm, myalgia

Ophthalmic: Eye pruritus, ocular hyperemia, swelling of eye, visual disturbance

Respiratory: Dyspnea, nasal congestion, pulmonary edema, sneezing, wheezing

Miscellaneous: Fever (neonates, infants, children, adolescents)

Frequency not defined: Cardiovascular: Cardiac arrhythmia

Postmarketing:

Dermatologic: Skin changes (plaques)

Gastrointestinal: Acute pancreatitis

Hypersensitivity: Anaphylactic shock, anaphylaxis

Respiratory: Acute respiratory distress syndrome

Contraindications

Hypersensitivity to gadobenate dimeglumine, any gadolinium-based contrast agent, or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Arrhythmias: Cardiac arrhythmias have been observed; use with caution in patients with predisposing proarrhythmic conditions or concurrent proarrhythmic drug therapy. Although average changes in QTc compared to placebo were minimal (<5 msec) and no patients experienced malignant arrhythmias, numerically more patients experienced QTc prolongation between 30-60 msecs and ≥61 msecs compared to placebo in one clinical trial.

• Extravasation: Vesicant; ensure proper needle or catheter placement prior to and during administration. Monitor infusion site. Avoid extravasation. May cause injection site reactions (local burning/pain, swelling, blistering, and necrosis).

• Gadolinium retention: Gadolinium is retained for months or years in brain, bone, skin, and other organs (kidney, liver, spleen); the highest concentration and longest duration have been found in the bone. Linear GBCAs (gadodiamide and gadoversetamide > gadoxetate disodium, gadopentetate dimeglumine, and gadobenate dimeglumine) result in more retention than macrocyclic GBCAs (gadoterate meglumine, gadobutrol, and gadoteridol). Pathologic and clinical consequences of gadolinium retention in skin and other organs have been established in patients with impaired renal function; there also have been rare reports of pathologic skin changes in patients with normal renal function. Consequences of gadolinium retention in the brain or in patients with normal renal function have not been established. Patients with normal renal function that may be at higher risk for gadolinium retention include: patients requiring multiple lifetime doses, pregnant and pediatric patients, and patients with inflammatory conditions; take GBCA retention characteristics into consideration for these patients. Minimize repetitive GBCA imaging studies.

• Hypersensitivity: Anaphylactic and anaphylactoid reactions (some fatal) have occurred (with cardiovascular, respiratory or dermatologic involvement); symptoms typically occurred within minutes of administration. Monitor patients closely during and for up to 2 hours after infusion. If hypersensitivity occurs, begin immediate management. Appropriate equipment (eg, ventilator) and emergency medications (eg, epinephrine) should be available during use. Delayed reactions may also occur (within several hours of administration). Patients with a history of allergic reactions and/or bronchial asthma may be at an increased risk for developing hypersensitivity reactions; use caution in these patients.

• Nephrogenic systemic fibrosis: The risk for nephrogenic systemic fibrosis (NSF) appears lower in patients with moderate, chronic renal disease (GFR 30 to 59 mL/minute/1.73 m2) and little, if any, in patients with mild, chronic renal disease (GFR 60 to 89 mL/minute/1.73 m2). In patients receiving hemodialysis, consider prompt initiation of hemodialysis following administration. If NSF occurs, report to manufacturer or the Food and Drug Administration (FDA).

Disease-related concerns:

• Metabolic disorders: May prolong systemic exposure with some drugs (eg, cisplatin, anthracyclines) due to competition for certain multispecific organic anion transporters (MOAT) especially in patients with decreased MOAT activity (eg, Dubin Johnson syndrome).

• Renal impairment: Use with caution in patients with renal impairment. Dose-dependent worsening of renal function or acute renal failure has occurred in patients with renal insufficiency following use of other gadolinium agents, generally within 48 hours following administration. Evaluate renal function in patients with renal impairment prior to use; consider follow-up monitoring.

Other warnings/precautions:

• Scan interpretation: Certain lesions may not appear with contrast-enhanced scan that do appear with noncontrast imaging; use caution when interpreting.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Intravenous [preservative free]:

MultiHance: 529 mg/mL (5 mL, 10 mL, 15 mL, 20 mL, 50 mL, 100 mL)

Generic Equivalent Available: US

No

Pricing: US

Solution (MultiHance Intravenous)

529 mg/mL (per mL): $6.81

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Intravenous:

MultiHance: 529 mg/mL (5 mL, 10 mL, 15 mL, 20 mL, 50 mL)

Administration: Adult

IV: Administer as rapid IV bolus injection. To ensure complete injection of medium, flush line with NS after administration using at least 5 mL (for CNS imaging) or at least 20 mL (for renal or aorto-ilio-femoral vasculature imaging). Do not administer other medications in the same IV line. May begin imaging immediately after administration.

Vesicant; ensure proper needle or catheter placement prior to and during infusion; avoid extravasation.

Extravasation management: If extravasation occurs, stop infusion immediately and disconnect; remove needle/cannula; elevate extremity. Aspiration of extravasated contrast media is not recommended (Ref). Information conflicts regarding the use of hyaluronidase; the American College of Radiology (ACR) Manual on Contrast Media does not recommend hyaluronidase in the management of contrast media extravasation (Ref); other sources suggest its utility in extravasation management for inoperable cases with compartment syndrome (Ref).

If using hyaluronidase: Intradermal or SUBQ: Dose varies based on the size of infiltration; inject a total of 5 to 250 units (~100 mL contrast reabsorbed per 15 units of hyaluronidase) around the site of extravasation (Ref).

Administration: Pediatric

IV: Administer as rapid IV bolus injection. To ensure complete injection of contrast medium, flush line with NS after administration, using at least 5 mL (for CNS imaging) or at least 20 mL (for renal or aorto-ilio-femoral vasculature angiography). Do not administer other medications in the same IV line.

Vesicant; ensure proper needle or catheter placement prior to and during infusion; avoid extravasation. If extravasation occurs, stop infusion immediately and disconnect; remove needle/cannula; elevate extremity; apply cold or warm compresses. Aspiration of extravasated contrast media is not recommended (Ref). Information conflicts regarding the use of hyaluronidase; the American College of Radiology (ACR) Manual on Contrast Media does not recommend routine use of hyaluronidase in the management of contrast media extravasation (Ref); other sources suggest its utility in extravasation management (eg, for inoperable cases with compartment syndrome) (Ref).

Medication Guide and/or Vaccine Information Statement (VIS)

An FDA-approved patient medication guide, which is available with the product information and as follows, must be dispensed with this medication;

MultiHance: https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/021357s028lbl.pdf#page=17

Use: Labeled Indications

CNS imaging: Magnetic resonance imaging (MRI) agent to visualize CNS lesions in adults and pediatric patients with abnormal blood brain barrier or abnormal vascularity in the brain, spine, and associated tissues

Renal and aorto-ilio-femoral vasculature imaging: Magnetic resonance angiography (MRA) agent to evaluate adults with known or suspected renal or aorto-ilio-femoral occlusive vascular disease

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Amisulpride (Oral): May increase QTc-prolonging effects of QT-prolonging Agents (Moderate Risk). Risk C: Monitor

Chloroquine: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Chloroquine. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Clofazimine: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Clofazimine. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Dabrafenib: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Dabrafenib. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Domperidone: QT-prolonging Agents (Moderate Risk) may increase QTc-prolonging effects of Domperidone. Risk X: Avoid

Encorafenib: May increase QTc-prolonging effects of QT-prolonging Miscellaneous Agents (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Fluorouracil Products: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Fluorouracil Products. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Haloperidol: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Haloperidol. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Levoketoconazole: QT-prolonging Agents (Moderate Risk) may increase QTc-prolonging effects of Levoketoconazole. Risk X: Avoid

Ondansetron: QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Ondansetron. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Pentamidine (Systemic): QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of Pentamidine (Systemic). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Pimozide: May increase QTc-prolonging effects of QT-prolonging Agents (Moderate Risk). Risk X: Avoid

Piperaquine: QT-prolonging Agents (Moderate Risk) may increase QTc-prolonging effects of Piperaquine. Risk X: Avoid

QT-prolonging Agents (Highest Risk): May increase QTc-prolonging effects of Gadobenate Dimeglumine. Management: Consider alternatives to this combination. If combined, monitor for QTc interval prolongation and ventricular arrhythmias. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk D: Consider Therapy Modification

QT-prolonging Antidepressants (Moderate Risk): May increase QTc-prolonging effects of QT-prolonging Miscellaneous Agents (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Antipsychotics (Moderate Risk): QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of QT-prolonging Antipsychotics (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Class IC Antiarrhythmics (Moderate Risk): QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of QT-prolonging Class IC Antiarrhythmics (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-Prolonging Inhalational Anesthetics (Moderate Risk): QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of QT-Prolonging Inhalational Anesthetics (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Kinase Inhibitors (Moderate Risk): May increase QTc-prolonging effects of QT-prolonging Miscellaneous Agents (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Miscellaneous Agents (Moderate Risk): May increase QTc-prolonging effects of Gadobenate Dimeglumine. Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Moderate CYP3A4 Inhibitors (Moderate Risk): May increase QTc-prolonging effects of QT-prolonging Miscellaneous Agents (Moderate Risk). QT-prolonging Moderate CYP3A4 Inhibitors (Moderate Risk) may increase serum concentration of QT-prolonging Miscellaneous Agents (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Quinolone Antibiotics (Moderate Risk): QT-prolonging Miscellaneous Agents (Moderate Risk) may increase QTc-prolonging effects of QT-prolonging Quinolone Antibiotics (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

QT-prolonging Strong CYP3A4 Inhibitors (Moderate Risk): May increase QTc-prolonging effects of QT-prolonging Miscellaneous Agents (Moderate Risk). Management: Monitor for QTc interval prolongation and ventricular arrhythmias when these agents are combined. Patients with additional risk factors for QTc prolongation may be at even higher risk. Risk C: Monitor

Sertindole: May increase QTc-prolonging effects of QT-prolonging Agents (Moderate Risk). Risk X: Avoid

Thioridazine: QT-prolonging Agents (Moderate Risk) may increase QTc-prolonging effects of Thioridazine. Risk X: Avoid

Reproductive Considerations

Evaluate pregnancy status prior to the use of gadolinium-based contrast agents in patients who may become pregnant (ACR 2023).

Pregnancy Considerations

Gadolinium-based contrast agents may cross the placenta (ACOG 2017; ACR 2023).

Outcome data following maternal use of gadolinium-based contrast agents during pregnancy are limited (ACR 2023).

Pregnant patients may be at increased risk for gadolinium retention. Use of gadolinium-based contrast agents in pregnancy is controversial and should be limited. A gadolinium-based contrast agent with MRI may be considered for use in pregnancy if it will significantly improve diagnostic performance and is expected to improve fetal or maternal outcome (ACOG 2017). In addition, use should only be considered if information needed from the MRI study cannot be acquired without using a contrast agent and cannot be deferred until after delivery. Agents with a low risk for development of nephrogenic systemic fibrosis should be used at the lowest effective dose (ACR 2023).

Breastfeeding Considerations

Gadolinium-based contrast agents may be present in breast milk (ACOG 2017; ACR 2023).

According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and the benefits of treatment to the mother. Because of the low expected excretion into breast milk and the low absorption from an infant's GI tract, breastfeeding may be continued without interruption after use (ACOG 2017; ACR 2023). Theoretically, the taste of milk could be altered if it contains contrast media. Patients who prefer to temporarily withhold breastfeeding may express and discard milk from both breasts during a period of 12 to 24 hours after the administration of contrast media. They can pump and store milk prior to the procedure then bottle feed using the stored milk during this time (ACR 2023).

Monitoring Parameters

Signs of hypersensitivity (during and for several hours after procedure); renal function (prior to administration); short- and long-term monitoring of signs and symptoms of NSF (eg, burning, itching, swelling, hardening and/or tightening of skin, joint stiffness, deep hip or rib bone pain, muscle weakness, limited range of motion, and/or yellowed/raised spots on whites of eye). Monitor infusion site. Evaluate pregnancy status prior to use in patients who may become pregnant (ACR 2023).

Mechanism of Action

Gadobenate dimeglumine is a gadolinium-containing paramagnetic agent. Exposure to an external magnetic field induces a large local magnetic field in exposed tissues. This local magnetism disrupts water protons in the vicinity, resulting in a change in proton density and spin characteristics, which can be detected by the imaging device.

Pharmacokinetics (Adult Data Unless Noted)

Distribution: Distributes mainly to extracellular space

Vd (central compartment):

Children 2 to 5 years: 0.2 ± 0.05 L/kg (Pirovano 2015)

Adults: 0.074 ± 0.017 to 0.158 ± 0.038 L/kg (Spinazzi 1999)

Vd (steady state): Children 2 to 5 years: 0.32 ± 0.04 L/kg (Pirovano 2015)

Vd (by area): Adults: 0.17 ± 0.016 to 0.262 ± 0.34 L/kg (Spinazzi 1999)

Metabolism: Gadobenate and dimeglumine dissociate after injection; pharmacokinetics are based on gadobenate; there is no additional biotransformation of gadobenate

Half-life elimination:

Distribution half-life:

Children 2 to 5 years: 0.13 ± 0.08 hours (Pirovano 2015)

Adults: 0.084 ± 0.012 to 0.605 ± 0.072 hours (Spinazzi 1999)

Elimination half-life:

Normal renal function:

Children 2 to 5 years: 1.22 ± 0.24 hours (Pirovano 2015)

Adults: 1.2 ± 0.09 to 1.96 ± 0.16 hours (Spinazzi 1999)

CrCl 30 to <60 mL/minute: 6.1 ± 3 hours

CrCl 10 to <30 mL/minute: 9.5 ± 3.1 hours

End-stage renal disease (ESRD) (without dialysis): 42.4 ± 24.4 hours

Excretion: Urine (78% to 96%); feces (0.6% to 4%)

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Altered kidney function: In patients with end-stage renal disease requiring hemodialysis, approximately 72% of the dose was recovered by hemodialysis over a 4-hour period.

Older adult: Clearance appeared to decrease slightly with increasing age.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AR) Argentina: Multihance;
  • (AT) Austria: Multihance;
  • (AU) Australia: Multihance;
  • (BE) Belgium: Multihance;
  • (BR) Brazil: Multihance;
  • (CN) China: Gadobenate dimeglumine | Mo di si;
  • (CO) Colombia: Multihance;
  • (CZ) Czech Republic: Multihance;
  • (DE) Germany: Multihance;
  • (FI) Finland: Multihance;
  • (FR) France: Multihance;
  • (GR) Greece: Multihance;
  • (HK) Hong Kong: Multihance;
  • (ID) Indonesia: Multihance;
  • (IT) Italy: Multihance;
  • (KR) Korea, Republic of: Multihance;
  • (MY) Malaysia: Multihance;
  • (NL) Netherlands: Multihance;
  • (NO) Norway: Multihance;
  • (PH) Philippines: Multihance;
  • (PT) Portugal: Multihance;
  • (PY) Paraguay: Multihance;
  • (RO) Romania: Multihance;
  • (RU) Russian Federation: Multihance;
  • (SE) Sweden: Multihance;
  • (SG) Singapore: Multihance;
  • (SI) Slovenia: Multihance;
  • (TR) Turkey: Multihance;
  • (TW) Taiwan: Multihance
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  2. American College of Radiology (ACR) Committee on Drugs and Contrast Media. ACR manual on contrast media. 2023. https://www.acr.org/-/media/ACR/Files/Clinical-Resources/Contrast_Media.pdf. Accessed May 17, 2023.
  3. American College of Radiology (ACR) Committee on Drugs and Contrast Media. ACR manual on contrast media. 2024. https://www.acr.org/Clinical-Resources/Clinical-Tools-and-Reference/Contrast-Manual. Accessed February 10, 2025.
  4. Bellin MF, Jakobsen JA, Tomassin I, et al; Contrast Media Safety Committee Of The European Society Of Urogenital Radiology. Contrast medium extravasation injury: guidelines for prevention and management. Eur Radiol. 2002;12(11):2807-2812. doi: 10.1007/s00330-002-1630-9. [PubMed 12386778]
  5. Joffe P, Thomsen HS, and Meusel M, "Pharmacokinetics of Gadodiamide Injection in Patients with Severe Renal Insufficiency and Patients Undergoing Hemodialysis or Continuous Ambulatory Peritoneal Dialysis," Acad Radiol, 1998, 5(7):491-502. [PubMed 9653466]
  6. Kuo PH, Kanal E, Abu-Alfa AK, et al, "Gadolinium-Based MR Contrast Agents and Nephrogenic Systemic Fibrosis," Radiology, 2007, 242(3):647-9. [PubMed 17213364]
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  8. MultiHance (gadobenate dimeglumine) [prescribing information]. Princeton, NJ: Bracco Diagnostics Inc; March 2025.
  9. MultiHance Pharmacy Bulk Package (gadobenate dimeglumine) [prescribing information]. Monroe Township, NJ: Bracco Diagnostics Inc; August 2024.
  10. Murashima M, Drott HR, Carlow D, et al. Removal of gadolinium by peritoneal dialysis. Clin Nephrol. 2008;69(5):368-372. [PubMed 18538100]
  11. Okada S, Katagiri K, Kumazaki T, et al, “Safety of Gadolinium Contrast Agent in Hemodialysis Patients,” Acta Radiol, 2001, 42(3):339-41. [PubMed 11350296]
  12. Pirovano G, Kirchin MA, Lorusso V, Patel R, Shen N. Pharmacokinetics of gadobenate dimeglumine in children 2 to 5 years of age undergoing MRI of the central nervous system. J Magn Reson Imaging. 2015;41(4):1096-1103. [PubMed 24807269]
  13. Reynolds PM, MacLaren R, Mueller SW, Fish DN, Kiser TH. Management of extravasation injuries: a focused evaluation of noncytotoxic medications. Pharmacotherapy. 2014;34(6):617-632. doi: 10.1002/phar.1396. [PubMed 24420913]
  14. Rowlett J, "Extravasation of Contrast Media Managed With Recombinant Human Hyaluronidase," Am J Emerg Med, 2012, 30(9):2102. [PubMed 22633726]
  15. Spinazzi A, Lorusso V, Pirovano G, Kirchin M. Safety, tolerance, biodistribution, and MR imaging enhancement of the liver with gadobenate dimeglumine: results of clinical pharmacologic and pilot imaging studies in nonpatient and patient volunteers. Acad Radiol. 1999;6(5):282-291. [PubMed 10228617]
  16. Stefanos SS, Kiser TH, MacLaren R, Mueller SW, Reynolds PM. Management of noncytotoxic extravasation injuries: a focused update on medications, treatment strategies, and peripheral administration of vasopressors and hypertonic saline. Pharmacotherapy. 2023;43(4):321-337. doi:10.1002/phar.2794 [PubMed 36938775]
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