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Summary of histologic classifications for celiac disease

Summary of histologic classifications for celiac disease
Marsh modified (Oberhuber) Histologic criterion Corazza
Increased intraepithelial lymphocytes* Crypt hyperplasia Villous atrophy
Type 0 No No No None
Type 1 Yes No No Grade A
Type 2 Yes Yes No  
Type 3a Yes Yes Yes (partial) Grade B1
Type 3b Yes Yes Yes (subtotal)  
Type 3c Yes Yes Yes (total) Grade B2
* >40 intraepithelial lymphocytes per 100 enterocytes for Marsh modified (Oberhuber); >25 intraepithelial lymphocytes per 100 enterocytes for Corazza.
Reprinted by permission from: Macmillan Publishers Ltd: American Journal of Gastroenterology. Rubio-Tapia A, Hill ID, Kelly CP, et al. ACG clinical guidelines: Diagnosis and management of celiac disease. Am J Gastroenterol 2013; 108:656. Copyright © 2013. www.nature.com/ajg.
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