NCI CTCAE v5.0 electrolyte abnormalities

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Hypercalcemia	Corrected serum calcium >ULN to 11.5 mg/dL; >ULN to 2.9 mmol/L; ionized calcium >ULN to 1.5 mmol/L	Corrected serum calcium >11.5 to 12.5 mg/dL; >2.9 to 3.1 mmol/L; ionized calcium >1.5 to 1.6 mmol/L; symptomatic	Corrected serum calcium >12.5 to 13.5 mg/dL; >3.1 to 3.4 mmol/L; ionized calcium >1.6 to 1.8 mmol/L; hospitalization indicated	Corrected serum calcium >13.5 mg/dL; >3.4 mmol/L; ionized calcium >1.8 mmol/L; life-threatening consequences	Death
Hyperkalemia	>ULN to 5.5 mmol/L (mEq/L)	>5.5 to 6.0 mmol/L (mEq/L)	>6.0 to 7.0 mmol/L (mEq/L); hospitalization indicated	>7.0 mmol/L (mEq/L); life-threatening consequences	Death
Hypermagnesemia	>ULN to 3.0 mg/dL; >ULN to 1.23 mmol/L		>3.0 to 8.0 mg/dL; >1.23 to 3.30 mmol/L	>8.0 mg/dL; >3.30 mmol/L; life-threatening consequences	Death
Hypernatremia	>ULN to 150 mmol/L (mEq/L)	>150 to 155 mmol/L (mEq/L)	>155 to 160 mmol/L (mEq/L); hospitalization indicated	>160 mmol/L (mEq/L); life-threatening consequences	Death
Hyperphosphatemia	Laboratory finding only and intervention not indicated	Noninvasive intervention indicated	Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated	Life-threatening consequences; urgent intervention indicated (eg, dialysis)	Death
Hyperuricemia	>ULN without physiologic consequences		>ULN with physiologic consequences	Life-threatening consequences	Death
Hypocalcemia	Corrected serum calcium <LLN to 8.0 mg/dL; <LLN to 2.0 mmol/L; ionized calcium <LLN to 1.0 mmol/L	Corrected serum calcium <8.0 to 7.0 mg/dL; <2.0 to 1.75 mmol/L; ionized calcium <1.0 to 0.9 mmol/L; symptomatic	Corrected serum calcium <7.0 to 6.0 mg/dL; <1.75 to 1.5 mmol/L; ionized calcium <0.9 to 0.8 mmol/L; hospitalization indicated	Corrected serum calcium <6.0 mg/dL; <1.5 mmol/L; ionized calcium <0.8 mmol/L; life-threatening consequences	Death
Hypokalemia	<LLN to 3.0 mmol/L (mEq/L)	<LLN to 3.0 mmol/L (mEq/L); symptomatic; intervention indicated	<3.0 to 2.5 mmol/L (mEq/L); hospitalization indicated	<2.5 mmol/L (mEq/L); life-threatening consequences	Death
Hypomagnesemia	<LLN to 1.2 mg/dL; <LLN to 0.5 mmol/L	<1.2 to 0.9 mg/dL; <0.5 to 0.4 mmol/L	<0.9 to 0.7 mg/dL; <0.4 to 0.3 mmol/L	<0.7 mg/dL; <0.3 mmol/L; life-threatening consequences	Death
Hyponatremia	<LLN to 130 mmol/L (mEq/L)	125 to 129 mmol/L (mEq/L) and asymptomatic	125 to 129 mmol/L (mEq/L) symptomatic; 120 to 124 mmol/L regardless of symptoms	<120 mmol/L (mEq/L); life-threatening consequences	Death
Hypophosphatemia	Laboratory finding only and intervention not indicated	Oral replacement therapy indicated	Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated	Life-threatening consequences	Death

Electrolyte abnormalities are all graded as Investigations. Serum calcium is corrected for albumin. Additional electrolyte abnormalities are included in the source document. A calculator for converting between standard and SI units is available in UpToDate.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events; ULN: upper limit of normal; LLN: lower limit of normal.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

Graphic 91252 Version 7.0

خرید پکیج

NCI CTCAE v5.0 electrolyte abnormalities