Role of obstructive events and carbon dioxide accumulation in obesity hypoventilation syndrome
Role of obstructive events and carbon dioxide accumulation in obesity hypoventilation syndrome
Schematic illustration of the primary end-point data obtained in the present study. (A) Spirometry tracing illustrating a postevent increase in ventilation to levels above control periods with stable ventilation. The immediate postevent ventilation was assessed by summing the tidal volumes for all breaths initiated within the first 10 seconds of the interevent period. (B) Graph illustrating the calculation of CO2 load during respiratory events. Thin line, average metabolic CO2 production over time; thick line, varying breath-by-breath CO2 excretion measured during changes in ventilation. CO2 load during event (shaded areas) is calculated by integrating the difference between breath-by-breath CO2 excretion and average metabolic CO2 production during the event.