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Bacitracin (topical): Drug information

Bacitracin (topical): Drug information
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For additional information see "Bacitracin (topical): Patient drug information" and "Bacitracin (topical): Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: US
  • FT Antibiotic [OTC]
Pharmacologic Category
  • Antibiotic, Topical
Dosing: Adult
Prevention of infection

Prevention of infection: Topical: Apply a small amount to the affected area 1 to 3 times daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Bacitracin (topical): Pediatric drug information")

Prevention of infection

Prevention of infection: Infants, Children, and Adolescents: Topical: Apply small amount 1 to 3 times daily; duration of therapy >7 days is not recommended, unless directed by health care provider. Note: Do not use in the eyes or over large areas of the body.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Postmarketing and/or case reports: Anaphylaxis (Elsner 1990; Farley 1995)

Contraindications

OTC labeling: When used for self-medication, do not use if hypersensitive to bacitracin or any component of the formulation.

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylaxis: Use with caution in patients who have been previously exposed to bacitracin; anaphylactic reactions have occurred on repeat exposure (Elsner, 1990; Farley, 1995).

Other warnings/precautions:

• Self-medication (OTC use): When used for self-medication (OTC), do not use in the eyes, over large areas of the body, or for longer than 1 week unless directed by health care provider. Discontinue use and notify health care provider prior to use for deep puncture wounds, bites, or serious burns; if condition persists or worsens; or if rash or other allergic reaction occurs.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External, as zinc [strength expressed as base]:

FT Antibiotic: 500 units/g (28.4 g)

Generic: 500 units/g (1 ea, 144 ea, 1 g, 14 g, 14.2 g, 15 g, 28 g, 28.35 g, 28.4 g, 30 g, 425 g, 453.9 g)

Generic Equivalent Available: US

Yes

Pricing: US

Ointment (Bacitracin External)

500 units/g (per gram): $0.08 - $0.12

500 units/g (per each): $0.14 - $0.23

Ointment (Bacitracin Zinc External)

500 units/g (per gram): $0.05 - $0.18

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: For topical use only; do not use in the eyes or over large areas of the body. Clean the affected area prior to use. Apply a small amount of product (an amount equal to the surface area of the tip of a finger); may cover with sterile bandage.

Administration: Pediatric

For external topical use only. Clean the affected area. Apply a small amount of product (an amount equal to the surface area of the tip of a finger); may cover with sterile bandage.

Use: Labeled Indications

Topical infection prevention: Prevention of infection in minor cuts, scrapes, or burns.

Medication Safety Issues
Sound-alike/look-alike issues:

Bacitracin may be confused with Bactrim, Bactroban

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Although large studies have not been conducted, absorption is limited following topical application; use during pregnancy has not been associated with an increased risk of adverse fetal events (Leachman, 2006; Murase, 2014).

Breastfeeding Considerations

Absorption is limited following topical application (Murase, 2014). Although large studies have not been conducted, use of topical bacitracin in breast-feeding women has not been associated with an increased risk of adverse events in the nursing infant (Leachman, 2006).

Mechanism of Action

Inhibits bacterial cell wall synthesis by preventing transfer of mucopeptides into the growing cell wall

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Poor from mucous membranes and intact or denuded skin

  1. Bacitracin ointment [prescribing information]. Livonia, MI: Major Pharmaceuticals; January 2020.
  2. Elsner P, Pevny I, Burg G. Anaphylaxis induced by topically applied bacitracin. Am J Contact Dermat. 1990;1(3):162-164.
  3. Farley M, Pak H, Carregal V, Engler R, James W. Anaphylaxis to topically applied bacitracin. Am J Contact Dermat. 1995;6(1):28-31.
  4. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24(2):167-197. [PubMed 16677965]
  5. Murase JE, Heller MM, Butler DC. Safety of dermatologic medications in pregnancy and lactation: part I. Pregnancy. J Am Acad Dermatol. 2014;70(3):1-14. [PubMed 24528911]
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