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Vitamin C (ascorbic acid): Drug information

Vitamin C (ascorbic acid): Drug information
2024© UpToDate, Inc. and its affiliates and/or licensors. All Rights Reserved.
For additional information see "Vitamin C (ascorbic acid): Patient drug information" and "Vitamin C (ascorbic acid): Pediatric drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: US
  • Acerola C 500 [OTC];
  • Asco-Tabs-1000 [OTC] [DSC];
  • Ascocid [OTC] [DSC];
  • Ascocid-ISO-pH [OTC] [DSC];
  • Ascor;
  • BProtected Vitamin C [OTC];
  • C-Time [OTC] [DSC];
  • Chew-C [OTC] [DSC];
  • Fruit C 500 [OTC];
  • Fruit C [OTC];
  • Fruity C [OTC];
  • True Vitamin C [OTC];
  • Vita-C [OTC];
  • VitaChew Vit C Citrus Burst [OTC]
Brand Names: Canada
  • Ascor L 500;
  • Mega-C-Sodium [DSC]
Pharmacologic Category
  • Vitamin, Water Soluble
Dosing: Adult
Ascorbic acid deficiency

Ascorbic acid deficiency: IM, IV, SUBQ: 70 to 150 mg daily is an average protective dose; doses 3 to 5 times the recommended dietary allowance may be adequate for conditions with increased requirements.

Burns, nutritional supplement

Burns, nutritional supplement (off-label use): Oral: 500 mg twice daily; continue until burn wounds are healed or patient is discharged (Ref).

Methemoglobinemia

Methemoglobinemia (off-label use): Note: Consider when methylene blue is contraindicated (eg, suspected or documented G6PD deficiency) or unavailable; dose based on limited data, optimal dose has not been identified.

Usual dose range: IV: 1 to 10 g every 6 hours until methemoglobin levels normalize (Ref).

Nutritional supplement

Nutritional supplement: Oral: 100 to 1,500 mg daily; dosage may vary depending on dosage form; consult specific product labeling.

Parenteral nutrition, maintenance requirement

Parenteral nutrition, maintenance requirement: IV: 200 mg/day (Ref).

Scurvy

Scurvy:

IM, IV, SUBQ: 300 to 1,000 mg daily; dose and duration of therapy should be individualized; doses up to 6 g per day have been administered (Ref).

Ascor: IV: 200 mg once daily for up to a maximum of 7 days. If no improvement after one week of treatment, retreat until resolution of symptoms is observed.

Oral: 100 to 300 mg daily until body stores are replenished; dose and duration of therapy should be individualized; doses as low as 10 mg may be effective (Ref).

Wound healing

Wound healing: IM, IV, SUBQ: 300 to 500 mg daily for 7 to 10 days pre- and post-operatively; larger doses have also been used.

Dosing: Kidney Impairment: Adult

Mild to severe impairment: There are no dosage adjustments provided in the manufacturer's labeling. Use with caution in patients with renal impairment or patients prone to recurrent renal calculi; may have increased risk of developing acute or chronic oxalate nephropathy.

ESRD (requiring hemodialysis):

Adults: IV, Oral: 60 to 100 mg once daily is sufficient to prevent serious ascorbate deficiency due to loss from dialysis; doses >100 mg daily may lead to secondary oxalosis and renal oxalate stone formation (Ref).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. Based on the pharmacokinetics of ascorbic acid, a water-soluble vitamin, a dosage adjustment does not seem necessary.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Vitamin C (ascorbic acid): Pediatric drug information")

Parenteral nutrition additive, maintenance requirement

Parenteral nutrition additive, maintenance requirement (Ref):

Infants: IV: 15 to 25 mg/kg/day; maximum daily dose: 80 mg/day.

Children and Adolescents: IV: 80 mg daily.

Scurvy, treatment

Scurvy, treatment:

Infants, Children, and Adolescents: Limited data available: Oral, IM, IV: Initial: 100 to 300 mg/day in divided doses for 1 week followed by 100 mg/day until normalization of tissue saturation (~1 to 3 months) (Ref).

Manufacturer's labeling: Ascor:

Infants ≥5 months: IV: 50 mg once daily for 1 week.

Children <11 years: IV: 100 mg once daily for 1 week.

Children ≥11 years and Adolescents: IV: 200 mg once daily for 1 week.

Dosing: Kidney Impairment: Pediatric

Mild to severe impairment: There are no dosage adjustments provided in the manufacturer's labeling. Use with caution in patients with renal impairment or patients prone to recurrent renal calculi; may have increased risk of developing acute or chronic oxalate nephropathy with high dose therapy.

ESRD (requiring hemodialysis): Children and Adolescents: IV, Oral: The KDOQI guidelines for nutrition in children recommend combined dietary and supplement intake should not greatly exceed the age-appropriate dietary reference intake; use caution in providing supplementation (Ref).

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. Based on the pharmacokinetics of ascorbic acid, a water-soluble vitamin, a dosage adjustment does not seem necessary.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Postmarketing:

Endocrine & metabolic: Hyperoxaluria (with large doses)

Hematologic & oncologic: Hemolysis (in patients with glucose-6-phosphate dehydrogenase deficiency)

Local: Pain at injection site, swelling at injection site

Contraindications

There are no contraindications listed in the manufacturer's labeling.

Warnings/Precautions

Concerns related to adverse effects:

• Oxalate nephropathy/nephrolithiasis: Acidification of the urine by ascorbic acid may cause precipitation of cysteine, urate or oxalate stones. Acute and chronic oxalate nephropathy has been reported with prolonged administration of high IV doses. Patients with renal disease including renal impairment, history of oxalate kidney stones, elderly patients and pediatric patients <2 years of age may be at increased risk. Monitor renal function in patients at increased risk. Discontinue in patients who develop oxalate nephropathy.

Disease-related concerns:

• Diabetes: Patients with diabetes mellitus should not take excessive doses for extended periods of time.

• Glucose-6-phosphatase dehydrogenase deficiency: Hemolysis has been reported in patients with glucose-6-phosphatase dehydrogenase (G6PD) deficiency and the risk for severe hemolysis may be increased during ascorbic acid therapy. Dose reductions may be necessary along with appropriate monitoring (eg, hemoglobin, blood counts). Discontinue treatment if hemolysis is suspected.

• Hemochromatosis: Use with caution in patients with hemochromatosis; excess ascorbic acid intake may increase the risk of adverse events (IOM 2000).

• Renal impairment: Use with caution in patients with renal impairment or patients prone to recurrent renal calculi; may have increased risk of developing acute or chronic oxalate nephropathy.

Special populations:

• Older adult: Use with caution in the elderly; may be at increased risk for oxalate nephropathy.

• Pediatric: Use with caution in the children <2 years of age; may be at increased risk for oxalate nephropathy due to immature kidney function.

Dosage form specific issues:

• Aluminum: The parenteral product may contain aluminum; toxic aluminum concentrations may be seen with high doses, prolonged use, or renal dysfunction. Premature neonates are at higher risk due to immature renal function and aluminum intake from other parenteral sources. Parenteral aluminum exposure of >4 to 5 mcg/kg/day is associated with CNS and bone toxicity; tissue loading may occur at lower doses (Federal Register 2002). See manufacturer's labeling.

• Benzyl alcohol and derivatives: Some dosage forms may contain sodium benzoate/benzoic acid; benzoic acid (benzoate) is a metabolite of benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol derivative with caution in neonates. See manufacturer's labeling.

• Injection: Avoid rapid IV injection; may cause temporary faintness or dizziness.

• Sodium: Some products may contain sodium; use with caution in sodium restricted patients.

Warnings: Additional Pediatric Considerations

Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution (AAP 1997; Shehab 2009).

Following ascorbic acid administration, pediatric patients <2 years of age are at a higher risk for oxalate nephropathy due to age-related decreased glomerular filtration; monitor renal function during ascorbic acid treatment; discontinue ascorbic acid if oxalate nephropathy develops and provide treatment.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule Extended Release, Oral:

C-Time: 500 mg [DSC]

Generic: 500 mg

Crystals, Oral:

Vita-C: (120 g, 480 g) [animal products free, gelatin free, gluten free, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Liquid, Oral:

BProtected Vitamin C: 500 mg/5 mL (236 mL) [contains propylene glycol, saccharin sodium, sodium benzoate; citrus flavor]

Generic: 500 mg/5 mL (120 mL, 473 mL)

Packet, Oral:

Generic: 500 mg (80 ea [DSC])

Powder, Oral:

Ascocid: (227 g [DSC])

Generic: (113 g, 120 g, 480 g)

Powder Effervescent, Oral:

Ascocid-ISO-pH: (150 g [DSC]) [corn free, rye free, wheat free]

Solution, Injection:

Generic: 500 mg/mL (50 mL [DSC])

Solution, Injection [preservative free]:

Generic: 500 mg/mL (50 mL)

Solution, Intravenous [preservative free]:

Ascor: 500 mg/mL (50 mL) [contains edetate (edta) disodium]

Tablet, Oral:

Asco-Tabs-1000: 1000 mg [DSC] [color free, starch free, sugar free]

True Vitamin C: 250 mg, 500 mg, 1000 mg

Generic: 100 mg, 250 mg, 500 mg, 1000 mg

Tablet, Oral [preservative free]:

Generic: 250 mg, 500 mg

Tablet Chewable, Oral:

Chew-C: 500 mg [DSC]

Fruit C 500: 500 mg [animal products free, gelatin free, gluten free, kosher certified, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Fruit C: 100 mg [animal products free, gelatin free, gluten free, lactose free, no artificial color(s), no artificial flavor(s), starch free, sugar free, yeast free]

Fruity C: 250 mg

VitaChew Vit C Citrus Burst: 125 mg

Generic: 100 mg, 250 mg, 500 mg

Tablet Chewable, Oral [preservative free]:

Generic: 500 mg

Tablet Extended Release, Oral:

Generic: 500 mg, 1500 mg

Wafer, Oral [preservative free]:

Acerola C 500: 500 mg (50 ea) [corn free, no artificial color(s), no artificial flavor(s), wheat free, yeast free; contains acerola (malpighia glabra)]

Generic Equivalent Available: US

May be product dependent

Pricing: US

Chewable (Vitamin C Oral)

500 mg (per each): $0.05 - $0.07

Liquid (BProtected Vitamin C Oral)

500 mg/5 mL (per mL): $0.06

Solution (Ascor Intravenous)

25000 mg/50 mL (per mL): $6.42

Solution (Ascorbic Acid Injection)

500 mg/mL (per mL): $2.04

Tablets (Ascorbic Acid Oral)

500 mg (per each): $0.04 - $0.05

Wafer (Acerola C 500 Oral)

500 mg (per each): $0.07

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Injection:

Ascor L 500: 500 mg/mL (50 mL) [contains edetate (edta) disodium]

Generic: 500 mg/mL (50 mL)

Solution, Injection, as sodium ascorbate:

Generic: 250 mg/mL (2 mL)

Administration: Adult

Oral administration is preferred unless malabsorption is suspected. IM administration is preferred when the parenteral route is required. Oral products may be administered with food.

Bariatric surgery: Capsule and tablet, extended release: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. Capsule may be opened and contents sprinkled onto soft food of choice. ER tablet should be switched to IR or chewable formulation.

Injection: For IM (preferred), IV, or SUBQ administration. Avoid rapid IV injection; may cause temporary faintness or dizziness.

Ascor: For IV use only. Following dilution in an appropriate IV solution (eg, D5W, SWFI), administer by slow IV infusion at a rate of 33 mg/minute.

Administration: Pediatric

Oral: Oral administration is preferred unless malabsorption is suspected. May be administered without regard to meals.

Parenteral:

Scurvy: IM, IV: Use only in circumstances when the oral route is not possible.

IM: Preferred parenteral route for some products due to improved utilization (refer to manufacturer labeling for appropriate products)

IV: Dose must be diluted prior to administration. Administer by slow IV infusion; rapid infusion (>250 mg/minute) may cause dizziness, nausea, lethargy, flushing, and headache.

Ascor: Doses should be infused at a rate not to exceed the following:

Infants 5 months to <12 months: 1.3 mg/minute

Children <11 years: 3.3 mg/minute

Children ≥11 years and Adolescents: 33 mg/minute

Use: Labeled Indications

Ascorbic acid deficiency: Treatment of symptoms of mild deficiency; use in conditions requiring an increased intake (eg, wound healing).

Nutritional supplement: As a dietary vitamin C supplement.

Parenteral nutrition, maintenance requirement: Prevent and correct vitamin C deficiency as a supplement to IV total parenteral nutrition.

Scurvy: Prevention and treatment of scurvy.

Use: Off-Label: Adult

Burns, nutritional supplement; Methemoglobinemia

Medication Safety Issues
International issues:

Rubex [Ireland] may be confused with Brivex brand name for brivudine [Switzerland]

Rubex: Brand name for ascorbic acid [Ireland], but also the brand name for doxorubicin [Brazil]

Metabolism/Transport Effects

None known.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Aluminum Hydroxide: Ascorbic Acid may increase the absorption of Aluminum Hydroxide. Management: In patients with severe renal dysfunction, consider avoiding this combination. Administering agents at least 2 hours apart may help minimize effects. Monitor for toxic effects of aluminum (from antacid) if ascorbic acid is coadministered. Risk D: Consider therapy modification

Amphetamines: Gastrointestinal Acidifying Agents may decrease the serum concentration of Amphetamines. Risk C: Monitor therapy

Bortezomib: Ascorbic Acid may diminish the therapeutic effect of Bortezomib. Management: Patients should avoid taking extra vitamin C supplements and vitamin C-containing multivitamins during their bortezomib therapy unless specifically recommended by their care provider. Risk D: Consider therapy modification

CycloSPORINE (Systemic): Ascorbic Acid may decrease the serum concentration of CycloSPORINE (Systemic). Risk C: Monitor therapy

Deferoxamine: Ascorbic Acid may enhance the adverse/toxic effect of Deferoxamine. Left ventricular dysfunction is of particular concern. Management: Limit the ascorbic acid dose to 200 mg/day (given in divided doses) in adult patients. In general, limit ascorbic acid to 50 mg daily for pediatric patients under 10 years old and 100 mg daily for older pediatric patients. Risk D: Consider therapy modification

Pregnancy Considerations

Animal reproduction studies have not been conducted. Maternal plasma concentrations of ascorbic acid decrease as pregnancy progresses due to hemodilution and increased transfer to the fetus. Some pregnant women (eg, smokers) may require supplementation greater than the RDA (IOM 2000).

Breastfeeding Considerations

Ascorbic acid is present in breast milk; regulatory mechanisms prevent concentrations from exceeding a required amount (IOM 2000). According to the manufacturer, the decision to breastfeed during therapy should take into account the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.

Dietary Considerations

Some products may contain sodium.

High dietary sources of ascorbic acid are citrus fruit, tomatoes/tomato juice, and potatoes; also found in other fruits, broccoli, cabbage, cauliflower, spinach, and strawberries. Absorption from diet and supplements is similar (IOM 2000).

Dietary recommended adequate intake (AI) (IOM 2000):

0 to 6 months: 40 mg daily

7 to 12 months: 50 mg daily

Dietary recommended daily allowance (RDA) (IOM 2000): Note: Patients with hemochromatosis, G6PD deficiency, and renal impairment may be at increased risk for adverse effects when exceeding recommended intake limits.

1 to 3 years: 15 mg daily; upper limit of intake should not exceed 400 mg daily

4 to 8 years: 25 mg daily; upper limit of intake should not exceed 650 mg daily

9 to 13 years: 45 mg daily; upper limit of intake should not exceed 1,200 mg daily

14 to 18 years: Upper limit of intake should not exceed 1,800 mg daily

Males: 75 mg daily

Females: 65 mg daily

Pregnant females: 80 mg daily; upper limit of intake should not exceed 1,800 mg daily

Lactating females: 115 mg daily; upper limit of intake should not exceed 1,800 mg daily

>18 years: Upper limit should not exceed 2,000 mg daily

Males: 90 mg daily

Females: 75 mg daily

Pregnant females: 19 to 50 years: 85 mg daily

Lactating females: 19 to 50 years: 120 mg daily

Adult smoker: Add an additional 35 mg daily

Monitoring Parameters

Renal function (patients at risk for developing oxalate nephropathy/nephrolithiasis); hemoglobin and blood counts (patients with G6PD deficiency).

Deficiency symptoms: May appear within 1 month of low intake (<10 mg/day) (ASPEN 2017; Vitamin C 2018). Symptoms include fatigue, malaise, corkscrew hair, and inflammation of the gums progressing to petechia, ecchymosis, purpura, joint pain, and poor wound healing.

Scurvy: Symptoms include depression; swollen, bleeding gums; loosening of teeth; and iron-deficiency anemia due to bleeding and decreased nonheme iron absorption (Vitamin C 2018).

Laboratory assessment: Plasma ascorbic acid is the preferred method of this vitamin's status (ASPEN 2017). Interpretation of plasma/ascorbic acid levels are as follows: Sufficient: >23 mcmol/L (0.4 mg/dL); Low: 12 to 23 mcmol/L (0.2 to 0.4 mg/dL); Deficient: ≤11 mcmol/L (0.2 mg/dL)

Mechanism of Action

Ascorbic acid is an essential water soluble vitamin that acts as a cofactor and antioxidant. Ascorbic acid is an electron donor used for collagen hydroxylation, carnitine biosynthesis, and hormone/amino acid biosynthesis. It is required for connective tissue synthesis as well as iron absorption and storage (IOM 2000).

Pharmacokinetics (Adult Data Unless Noted)

Onset of action: Reversal of scurvy symptoms: 2 days to 3 weeks

Absorption: Oral: Readily absorbed in the intestine; an active process thought to be saturable and dose dependent (30 to 180 mg/day: 70% to 90%; >1,000 mg/day: ≤50%) (IOM 2000)

Bioavailability: Oral: For doses up to 200 mg, nearly 100%; declines with increasing doses with ~33% for a single dose of 1250 mg (Schwedhelm 2003)

Distribution: Pituitary and adrenal glands, leukocytes, eye tissues and humors, and brain; lower concentrations in the plasma and saliva (IOM 2000)

Metabolism: Reversibly oxidized to dehydroascorbic acid (DHA); both ascorbic acid and DHA are active. Unabsorbed ascorbic acid is degraded in the intestine (IOM 2000)

Half-life elimination: 10 hours (Schwedhelm 2003). Biological half-life: 8 to 40 days (IOM 2000)

Excretion: Urine (with high serum concentrations) (IOM 2000); there is an individual specific renal threshold for ascorbic acid; when blood levels are high, ascorbic acid is excreted in urine, whereas when the levels are subthreshold (doses up to 80 mg/day) very little if any ascorbic acid is excreted into urine

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Additiva vit c | C 1000 | C 500 | Cebion | Ceelin | Limcee | Mr Tumee Vitamin C | Nature Made Vitamin C | Redoxon | Sunkist Vitamin c | Tiny C | Vagi c | Vitamin C | Vitamin c with rose hips;
  • (AR) Argentina: Activit | Cebion | Cewin | Gynefix | Naral Vitamina c | Plenovit vitamina c | Redoxitos | Redoxon | Tanvimil c | Vicenrik | Vitace | Vitamina C | Vitamina c complex | Vitamina c+c;
  • (AT) Austria: Ascorbin | C vit | Cebion | Cetebe | Cevitol | Mel c | Redoxon | Vitamin C;
  • (AU) Australia: Australian Naturalcare Products VitaminC | Bio c | Bioglan cal c | Bioglan junior vit c | Bioglan mega c | Bioglan one a day vitamin c | Bioglan vitamin c | Blackcurrant C | Blackmores vitamin c | C-ultrascorb | Cenovis mega c | Cenovis sugarless c | Cenovis vit c | Chemmart pharmacy vitamin c | Cm vitapak vit c | Delrosa | Enervite Vitamin C | Ester c | Faulding remedies vitamin c | Gold cr vit c | Gold cross vitamin c | Gold cross vitamin c orange | Healthy care vitamin c | Herb Valley Vitamin C | Herron bio c | Herron hl031 clin. nutr. vit c s. free vit c | Herron hl685 vitaminis tropical vitaminc | Herron vitamin c | Hi c low acid | Hivita vitamin c | Living healthy vitamin c | Mega c | Metab c | Metabolite c | N/w total c | N/w vitamin c | Natures Care Vitamin C | Oviit vitamin c 500 | Pharmacy health vitamin c | Quality health vitamin c | Redoxon | Ribena | Smiles kids vit c | Sugarless C | Super natural c | Swisse ultiboost high strength c | Terry white chemist vitamin C | U-viva vit c | Ultra potent c | Vg mega c | Vit c orange | Vit c rosehip | Vit c+r/hip | Vita valu vit c | Vita-tingles vit c | Vitamax Vitamin C | Vitamin c | Vitamin C | Vitamin c acid | Vitamore vitamin c | Vitaplex mega c | Vitaplex vit c | Vitelle calc ascrb | Vitelle sugarless c | Vitelle vit c | Voost vitamin c | Your Pharmacy Vitamin C;
  • (BD) Bangladesh: Ascobex | Ascorbon | Ascoson | Ascovit | C | C-Bon | Capcee | Cecon | Ceeimet | Ceevit | Ceevit ds | Celin | Cevalin | Chemo C | Chewce | Chewvit | Citavit | Citlets | Dc-Vit-C | G-vitamin c | Gevit | Hi-C | Kvit c | Lemovit c | Neocee | Nutrivit C | Ovit c | Seema c | Suvic | Vasco | Veesina | Vit c | Vitace | Vitamin C;
  • (BE) Belgium: C will | Cetamine | Cevidrops | Cevitine | Redoxon | Upsavit c | Vit c roter | Vitamine c-ojg novum pharma;
  • (BG) Bulgaria: Ceviton | Jamieson Vitamin C | Vitamin C;
  • (BR) Brazil: Acerogrip c | Biovita C | C 1000 pura | C 500 pura | C fonty | C rolla | Cebion | Cetivit | Cevita | Cewin | Citroplex | Citrovit | Conthenc | Coristina vitamina c | Energil c | Energrip c | Energyfor c | Ester-c | Fonto-vit c | Ftb vitamina c | Redoxon | Sundown high potency pure Vitamin C | Vagi c | Vagivit | Vi-ce | Vitacitrus | Vitamice | Vitamin C | Vitamina C | Vitamina c medquimica | Vitaminas c | Vitasantisa c | Viter c | Vitergyl c | Viterkids Vitamina C;
  • (CH) Switzerland: Burgerstein Vitamin C | Redoxon | Redoxon fruchtaroma | Vitamin C Streuli;
  • (CI) Côte d'Ivoire: Vit c | Vitamine c Aguettant | Vitascorbol;
  • (CL) Chile: Acido ascorbico | Cebion | Crevet | Crevet l | Esvit C | Mi vit c | Necta C | Redoxon | Vi c | Vitamina C;
  • (CN) China: De wei xi | Vitamin C | Wei ti yin;
  • (CO) Colombia: Acido ascorbico | Ascorbato de sodio | Biogrip | C grip | Cebion | Cebion minis | Cevalin | Cevimax | Cevit | Devit c | Lemovit | Pascorbin | Vical | Vicitra | Vita c | Vitace | Vitacnova | Vitacrest | Vitamin C | Vitamina C | Vitamina c mk | Vitfar c | Wei c;
  • (CZ) Czech Republic: Apo c | Biovital c | Celaskon | Multi tabs vit.c | Vitamin C;
  • (DE) Germany: Abtei vitamin c | Additiva vitamin c | Aminoslim | Apfelsine vitamin c | Aponeo vitamin c | Ascorbinsaeure | Ascorvit | Beifuss | Benevit c | Bio vitamin c | Biocerola | C will | Cadion Acerola | Calcium Ascorbat | Cebion | Cekind | Ceretard | Cetebe | Citrovit | Forum c | Gib vitamin c | Medifit Vitacit | Megadyn Vitamin C | Meta care vitamin c spezial | Nobilin Vitaplus C | Oekothek vit c depot | Ogima pro vitamin c | Orthica Dino C | ORTHODOC VITAMIN C | Pascorbin | Phaona Vitamin C | Pure Encapsulations Vitamin C | Sanddorn C Cerola Taler | Sauregepuffertes vitamin C | Synum | Taxofit vitamin c | Vagi c | Vitamin C | Vitamin c crownvita | Vitamin c menssana | Vitamin c mp | Vitamin c mse matrix | Vitamin c pascoe | Vitamin c vegi | Wellbo vitamin c;
  • (DO) Dominican Republic: C 1000 | Cebion | Cebion Tropical | Cevitran | Lemovit LS | Mason Vitamina C | Redoxon | Vitamina C | Vitamina C Mason;
  • (EC) Ecuador: Acido ascorbico | Antiros | Ascorvit | C SA | C-500 | Cebion | Cebion minis | Cemin | Cevit | Citrovit LS | Condrosol | Crevet | Dul c vit | Orange c | Pascorbin | Redoxon | Vagivit | Vascuvera | Vitamina C | Vitamina c la sante | Vitamina c mk | Vitamina c nifa;
  • (EE) Estonia: A. c vitamiin maasikamaitseline | Acerola c vita | Acerola sweet | Acidum ascorbinicum | Apovit C Vitamin | Apovit c-vitamin | Brontici vit c | Cecko | Celaskon | Chewy c | Disney C Vitamin | Ester c | Feminella vagi c | Futura hip | Grindevits c | Gritamin c vitamiin | Krugeri c vit | Linamon | Liposomal c-vit | Liposomal vitamin c | Livol vit.c | Livsane vitamin c | Now C 500 | Puru c | Room vitamiin c | Sano-swizz-c | Upsa vitalite | Vita c | Vitam.marja | Vitamiin c | Vitamiin c mittehappeline | Vitamin C | Vitamin c citrus | Vitamin c grape | Vitamin c hl | Vitamin c orange | Vitamin c pro expert | Vitamin c pro forte | Vitasorb c;
  • (EG) Egypt: C retard | C viton | Cevarol | Ester c | Ester-c | Fruitamin Plus | Orangina c | Ultra c | Vita c | Vitacid c | Vitamin C | Vitascorbol;
  • (ES) Spain: Acido Ascorbico Pharma Nord | Cebion | Redoxc | Redoxon | Upsa c;
  • (FI) Finland: Ascorbin | Ascorbin c vitamin leiras | Bio C Vitamin | C vitamin | C-vitan | Cevi-tabs | Multivita ascorbin long | Puru c | Vires c | Vita c;
  • (FR) France: Arkovital c | Ascorbate de calcium richard | Dynascorbine | Laroscorbine | Vitaminas c | Vitamine c Aguettant | Vitamine c merck | Vitamine c pch | Vitamine c upsa | Vitascorbol;
  • (GB) United Kingdom: Ascorbic acid almus | Ascorbic acid cox | Ascorbic acid kent | Ascorbic acid sandoz | Ascorbic acid zanza | Crookes | Numark vitamin c | Redoxon c | Roscorbic | Valupak vitamin c | Vitalife vit c | Vitamin C | Vitamin c kent;
  • (GH) Ghana: Citro c;
  • (GR) Greece: Ascorbine | Cebion | Pascorbin | Redoxon;
  • (HK) Hong Kong: Appeton Vitamin C | Ascormin c | Cecap | Cetrinets | Cevit | Champs Junior | Chewa C | Chewable c | Chewette c | Eurosee | Flavettes | Growvit C | Hudson vitamin C | Nutribes vitamin c | Redoxon | U Vitamin C | Vidafilm C | Vitamin C | Vorange | Win C;
  • (HR) Croatia: Natural Wealth Vitamin C-500 | Plivit c;
  • (HU) Hungary: Beres c vitamin | Beres c-vitamin | C vitamin | Cetebe | Eurovit c vitamin | Vitamin C;
  • (ID) Indonesia: Askorbin | Bekamin c | C face white c serum | Candy vitamin c | Cebion | Emkavit c | Lemon c | Leovita c | Natur-c | Natural factors vitamin c | Pehacimin | Poncocee | Redoxon | Super ester c | Sweeta c | Tabsi | Vicee | Vita c | Vitacimin | Vitalong c trc | Vitamex c | Vitamin C | Vitamin c flavour | Xon-ce | Zevit c;
  • (IE) Ireland: Lifeplan vitamin c | Redoxon | Rubex | Sanatogen vitamin c | Sona vitamin c;
  • (IL) Israel: C | C Tamin | Vitamin C;
  • (IN) India: Alcee | C shine | C vit | Cecon | Celin | Cell-c | Chewcee | Citravite | Eldervit | Epi | Frutcee | Limcee | Redoxon | Scorbix | Sukcee | Swicee | Vc | Vitamin C | Vitcee;
  • (IQ) Iraq: Vitamin C | Vitamin c kind | Vitan c;
  • (IT) Italy: Acido ascorbico | Agrumina | Agruvit | Ascocid | C monovit | C-Tard | Cebion | Duo c | Redoxon | Vici | Vitamina C | Vitamina c | Vitamina c salf | Vitamina C Vita;
  • (JO) Jordan: Appeton a-z kid's vitamin c | Appeton Vit C | Jamieson Vitamin C | Kamu | Mega c | Redoxon | Sun c | Univit-c | Vit c | Vitamin C;
  • (JP) Japan: Actamin c | Actamin c towa | Ascoltin | C Tuck | C tuck isei | C tuck teisan | Carashimin c | Contac vitamin c | Hicee | Lemona c new | Viscorin | Vita c | Vitacimin | Vitamin c alfresa | Vitamin c fuso | Vitamin c iwaki | Vitamin c nipro | Vitamin c takeda | Vitamin c towa | Vitamin c white;
  • (KE) Kenya: Appeton a-z kids vitamin c | Appeton activ c | Ascovite | Limcee | Neolife vitamin c | Vitamin C;
  • (KR) Korea, Republic of: Asco | Ascorbic acid doosan | Asvin | Bbc vaginal | C-all | Cantan | Ckd vitamin c | Cmg ascorbic acid | Daewoong c | Korea eundan vitamin c | Korus ascorbic acid | Kukje ascorbic acid | Newtral C | S.n.c. | Serom | Solasyl | Vagi c | Vita c | Vitalemon c | Vitamin C | Vitamin c guju | Vitamin c kwangil | Yuhan vitamin c;
  • (KW) Kuwait: C vitamin | Cebion | Cenovis Vitamin C | Chewable c | Defender C | Jamieson Vitamin C | Nature Made Vitamin C | Redoxon | Sunny Maid Vitamin C | Supravit Energy C | Vita c | Vitamin C;
  • (LB) Lebanon: Ascorbic | Buffered c | C retard | C vit | Cebion | Healtheries vitamin c | Herb Valley Vitamin C | Juvamine vitamine c | Mason Vitamin C | Natural wealth vitamin c | Redoxon | Sunny Made Vitamin C | Vit c | Vitamin C | Vitascorbol;
  • (LT) Lithuania: Acidum ascorbin | Acidum ascorbinicum | Apovit vitamin c | Asvitol | Benu vitamin c | Brixcli c | Brontici | Cecko | Celaskon | Cetebe | Cevikap | Childlife Vitamin C | Feminella vagi c | Gritamin c complex | Highway vit.c | Livol c | Megacecko | Megavit c | Natural c vita | Super vitaminas c | Taxofit c | Upsavit c | Vita c | Vita c natural | Vitamin c | Vitamin C | Vitamin c formula | Vitamin c pro forte | Vitamin c prolong | Vitaminas c | Vitaminas C Gamtos Namai | Vitaminas c vivavit | VitaTonale Vitamin C | Xylisweet acerola | Yl vitamin c | Zdrovit vit c;
  • (LU) Luxembourg: C will | Cebion | Cetamine | Cevidrops | Redoxon | Vitamine c | Vitascorbol;
  • (LV) Latvia: Acerola c vita | Acidum ascorbinicum | Ap vit ce cranb | Apovit-vitamin c | Ascorbinka | Ascovit | Askorbinovaya kislota | Askorbinskabe | Asvitol | Benu c vitamins | Brontici | C vit | C vita | Celaskon | Childlife Vitamin C | Ester c | Feminella vagi c | Forsivit balance | Futura hip | Grindevit c | Grindevit mini c | Gritamin c vitamins | Livol mono extra vitamin c | Livol vitamin c | Livsane c vitamins | Plivit | Sunlife vit c | Vitamin C | Vitamin c Highway | Vitamin c mezaogu | Vitamin c Valentis | Vitamin c75 | Vitamins c | Walmark mega c ar apelsinu | Yl natural time rose | Yl natural vitamin c | Zdorovit vit.c | Zdrovit vit c;
  • (MA) Morocco: Laroscorbine | Vitascorbol;
  • (MX) Mexico: Acid.ascorb.gi pha | Acido ascorbico | Adelitese | Amsac | Aservit-c | C 1000 | C 500 | C 500 buffered | C diaben | C one gram | C suave | C-messel | Cebion | Cemina | Ckanin | Dul c vit | Femiprim | Forti kids | Infa-c-vit | Infalet | Kirkland signature Vitamin C | Nature made c | Ramico | Ramy-ce | Rdp | Redoxon | Redoxon forte | Redoxon infantil | Rosavit-c | Tec Vital | Vitamina C | Vitamina c gi | Vitamina c grin;
  • (MY) Malaysia: Acid Free C | Acid-free c | Appeton a-z kids vitamin c | Appeton activ c | Appeton Vitamin C | Ascorbic | Ascorbin | Aspen c vita | Beacon-c | Bio-sustain C | Blackmores vitamin c | Buffered Orange C | Cecap | Cetrinets | Champs | Champs c | Chewette C | Chewies | Chewies plus vitamin C | Citrex junior | Citrex vitamin C | Dyna c | Flavettes | Flavettes time release c with calcium | Hipoten C | Hovid chewette C | Limcee | Nova c 500 | Orange c | Redoxon | Roscep | Shine vitamin c | Total c | Vidaylin c junior | Vitacee | Vitacimin | Vitamin C | Vitamin c | Vitasen vitamin c | Xepa C | Zhubee vitamin c;
  • (NG) Nigeria: Agecee | Alben c | Apacco vitamin c | Archy ascorbitone | Ascochew | Ascomed | Ascorvit | Avro c | Biocee vitamin c | Bioracee | Bolar c | Bond vitamin c | Gauze vitamin c | Gentlehills vitamin c | Muchis c | Navic | Nuel vitamin c | Nuel vitamin c orange flavour | Pal vitamin c | Spartan c | Surelife vitamin c orange flavoured | Top cee | Vita ace | Vitamin C | Zing c | Zuvit c;
  • (NL) Netherlands: Ascorbinezuur | Ascorbinezuur CF | C will | Dayvital | Redoxon | Roter vitam.c;
  • (NO) Norway: Bio C Vitamin | Nycoplus c spesial | Nycoplus c-vitamin;
  • (NZ) New Zealand: Amcal vitamin c | Apo-ascorbic acid | Better you vitamin c | Cenovis mega c | Cenovis sugarles c | Cenovis Vitamin C | Citravite | Cvite | Ester c | Exclusive vitamin c | Family vitamin pack | Go vitamin c | Incremin vitamin c | Kidscare vitamin c | Nature's own vitamin c vita jellies | Natures Sunshine Children's Vitamin C | Nutra life vitamin c | Redoxon | Solgar chewable vitamin c | Swisse vitamin c chewable | Ultiboost high strength c | Ultra c | Vitamin C | Vitamin c natural wildberry chewable | Vitamin c plus | Wagner ester c;
  • (PE) Peru: Ascorbil | C vimin | Cerovit c rose hips | Crevet | Gnc vitamin c | Redoxon | Sundown naturals Vitamin c | Sunvit vitamina c | Supervit | Vitacimin | Vitamina C;
  • (PH) Philippines: 24 alkaline c | Alka C | Alka-cee | Asconvita | Ascophil | Ascor cee plus | Ascorbic Acid United home | Bescee | Bewell C | Boie c | Bonalet-cee | Bone cee | Cal cee | Calcimed | CareZee | Cecon | Cee protect | Ceetab | Cetrasol | Cetrin | Cetrinets | Cetrinets fruteez | Cetrinets Hello Kitty | Cevit | Champs c | Citrucin | Cixtor | Corcebic c | Daycee | Esvicee | Excel C | Ezz-c | Fern C | Florvit c | Fora cee | Gen cee | Guard c | Harcee | Iconcee | Incee-vit | Lemon cee | Lemoncee | Mega c | Meyerf ascorbic acid | Myrevit C | Nutricee | Oren c | Poten-cee | Pro c | Selvon Cee | Sodium ascorbate ritemed | Tee Zee | Tgp cee | Time cee | Tropicee | United home ceetab premium | Vamcee | Vitamin C | Winthrop sodium ascorbate | Zerrucee;
  • (PK) Pakistan: Ascorbon | Ascorcid | Ascorvit | Atcocee | Cecon | Citrovit c | Corbic c | Elvit c | Paragin | Pop C | Redoxon | Semo-c | Sorbic | Ultravit-c | Vitacimin | Vitamin C | Zacocee;
  • (PL) Poland: Ascovita | Cebion | Celaskon | Cetebe | Ceviforte c | Dolovit vit c | Medicaline liposol vitamin c | Multi tabs vit.c | Redox c | Top c | Vibovit c | Vicefar | Vicevit | Vita care c-long | Vitamin C | Vitaminum c;
  • (PR) Puerto Rico: C | Cevita | Sunkist vitamin c chewable | Vit c | Vitamin C;
  • (PT) Portugal: Acido ascorbico | Redoxon;
  • (PY) Paraguay: C vimin | Gnc vitamin c | Maxivit c | Neovit c | Redoxon | The vitamin shoppe c | Vagivit | Vitamina c 500 mg lasca | Vitamina c 500 mg. asfarm | Vitamina c genfar | Vitamina c indufar | Vitamina c nutri force | Vitamina c parafarma | Vitasan c;
  • (QA) Qatar: 21st Century Vitamin C-1000 | Ascorb | Bell's Vitamin C | C-Viton | Ceemax | Cevitil | Cyclo3 Fort | Ester-C Vitamin C Prolong | Genesisvit | NatureCare Effervescent Vitamin C | Redoxon | Ruta C | Selovita-C | Vit C High Strength | Vita-C;
  • (RO) Romania: Ascovit | Brontisori | Cetebe | Vitamedi c | Vitamina C;
  • (RU) Russian Federation: Acidum ascorbinicum | Ascorbic acid granulate | Ascorbic acid ubf | Asvitol | Biovital c | Celascon effect vitamin c | Dinozavriki | Dnkac | Helacin c | Immunostart | Rostvit | Tinrostym st+ | Upsavit vitamin c | Vitamin C | Vitamin c beres | Vitamin c orange | Vitamin c plus | Vitamin c-75;
  • (SA) Saudi Arabia: Cebion | Redoxon | Vita c | Vitamin C;
  • (SE) Sweden: C vimin | C vitamin | Cebion | Ido-c;
  • (SG) Singapore: Acid Free C | Appeton a-z kid's vitamin c | Appeton activ c | Appeton active C | Appeton Vitamin C | Ascorbin | Big friends chewable vitamin c | Bio Ester C | Blackcurrant C | Blackmores vitamin c | Cecap | Celin | Cetebe | Cetrinets | Cevit | Champs c | Chewable c | Chewette c | Chewy c | Childrens vitamin C | Ester c | Evans high potency vitamin c | Flavettes | Hicee | Mango C | Orange c | Redoxon | Trn Mega C Vita | Vitamin C | Vorange | Xepa C;
  • (SI) Slovenia: Acerola sweet | Feminella vagi c | Vitamin C;
  • (SK) Slovakia: Celaskon | Plivit c | Vitamin C;
  • (SL) Sierra Leone: Citro c | Mincy;
  • (TH) Thailand: Ascee | Ascorb | Bio-vitamin c | Buffet c | C mile | C mon | C Morvit | C vit | C will | C-mic | Cecap | Cee | Ceelac | Cibic | Dancimin-c | Fa c | Flavettes | Gnc prima-c | Gnc vitamin c | Indovit | Lynae vitamin c | Maxcee | Med C | Mega c | Mymin C | Nat C | Nk c-naturel | Redoxon | Sweetcee | Teddy-c | Tomehour super c | Vistar C | Vit c 25 frx | Vit C Frx | Vit c-mile | Vitacee | Vitacimin | Vitacimin Sweetlets | Vitamin C | Vitamin-c | Vitaminas c | Vitbun 50 C | Zee;
  • (TN) Tunisia: Laroscorbine | Vitascorbol;
  • (TR) Turkey: Bio C Vitamin | C plan | C vit | Ester c | Ester-vit | Kangavites Vitamin C | Nature's bounty vitamin c | Oro vitamin c | Redoxon | Solgar Vitamin C | Sunlife vitamin c | Time Release Vitamin C | Vagi c | Vita Gummys Vitamin C | Vitamin C | Voonka vitamin c;
  • (TW) Taiwan: Ascolin | Ascormin | Astro c | Bowlin-c | Ceetomin | Cero | Cicimei | Civic | Duocee | Fancy | Flavettes | Gentle-c | Green-c | Instacon-c | Instamin-c | Jamen | King fancy | Opal-c | Robosin | Sylvia | Take-c | Viscorbic | Vitacicol | Vitacide | Vitamin C | Yami vitamin c | Yih Meeishi | Yu Sheng C;
  • (UA) Ukraine: Acidum ascorbinicu | Beres c vitamin | Multi tabs vitamin c | Upsavit vitamin c | Vitamin C | Vitamin c plus;
  • (UG) Uganda: Agog c | Vitacee | Vitamin C;
  • (UY) Uruguay: C 1000 | C vit | Cebion | Corbic | Vitamina C;
  • (VE) Venezuela, Bolivarian Republic of: Acido ascorbico | Ascorbit | C vitamin | Cebion | Cevax | Cevit | Ester-c | Natural systems Vitamin C | Redoxon | Vitadyn c | Vitamina C | Vitamina c genven | Vitrexon;
  • (VN) Viet Nam: Agi vitac;
  • (ZA) South Africa: Absolute c | Alpha vit c | Be-tabs ascorbic acid | Be-tabs chewy c | Bettaway vitamin c | Brainchild vitamin c | Chewette C | Chewy c | Double vitamin c | Heart and nerve white | Scorbex | Smart c | Vitaforce massif-c | Vitaforce vitamin c | Vitamin C | Wellvita vitamin c;
  • (ZM) Zambia: Absorbent c | Ago c | Ar vitacee | Asbic | Be-tabs chewy c | C vit | Cevin | Cevite | Dyna c | Vitacee;
  • (ZW) Zimbabwe: Medox C Forte | Vitamin C
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