ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -49 مورد

Levodopa and benserazide (United States: Not available): Drug information

Levodopa and benserazide (United States: Not available): Drug information
2025© UpToDate, Inc. and its affiliates and/or licensors. All Rights Reserved.
For additional information see "Levodopa and benserazide (United States: Not available): Patient drug information"

For abbreviations, symbols, and age group definitions show table
Brand Names: Canada
  • Prolopa 100-25;
  • Prolopa 200-50;
  • Prolopa 50-12.5
Pharmacologic Category
  • Anti-Parkinson Agent, Dopamine Agonist
Dosing: Adult
Parkinson disease

Parkinson disease: Adults ≥25 years of age:

Note: Dosage should be introduced gradually, individualized, and continued for 3 to 6 weeks before assessing benefit. Available formulations include benserazide 25 mg/levodopa 100 mg, benserazide 50 mg/levodopa 200 mg, and benserazide 12.5 mg/levodopa 50 mg. Benserazide 50 mg/levodopa 200 mg formulations should be used only when maintenance therapy is reached. Benserazide 12.5 mg/levodopa 50 mg formulations should be used to minimize adverse effects when adjusting dose.

Oral:

Initiation: Benserazide 25 mg/levodopa 100 mg once or twice daily; increase dose by benserazide 25 mg/levodopa 100 mg every 3 to 4 days or slower (eg, weekly) if problems with tolerance until adequate therapeutic effect without dyskinesias; reduce frequency of dosage adjustments to every 2 to 4 weeks as upper limits of dosing range is approached.

Usual maintenance dosage: Benserazide 100 mg/levodopa 400 mg to benserazide 200 mg/levodopa 800 mg daily given in 4 to 6 divided doses; after maintenance dose of benserazide/levodopa is established, slowly decrease dose of levodopa by 50 mg per month over a few months until a maintenance dose without dyskinesias is achieved.

Maximum: Total daily dose of levodopa during the first year of therapy should not exceed 1,000 mg to 1,200 mg/day. Following first year, the maximum recommended daily dose of levodopa is 600 mg/day.

Restless legs syndrome, intermittent

Restless legs syndrome, intermittent (alternative agent) (off-label use):

Note: Due to risk of augmentation (worsening symptoms during dopaminergic therapy), limit frequency to 2 to 3 administrations per week. May also be taken as needed prior to specific restless legs syndrome triggers, such as prolonged immobility (Ref).

Oral: Initial: Benserazide 25 mg/levodopa 100 mg as needed before bedtime; may increase to benserazide 50 mg/levodopa 200 mg based on response and tolerability. Maximum: levodopa 200 mg/day (Ref).

Discontinuation of therapy: Discontinuation of therapy may result in neuroleptic malignant-like syndrome (Ref). Avoid sudden discontinuation or rapid dose reduction; some experts recommend a gradual taper over several weeks or more (Ref).

Dosage adjustment for concomitant therapy: Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in manufacturer's labeling. Use in decompensated renal disease is contraindicated.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in manufacturer's labeling. Use in decompensated hepatic disease is contraindicated.

Dosing: Adjustment for Toxicity: Adult

Patients experiencing dystonia: There are no specific dosage recommendations provided in the manufacturer’s labeling however a levodopa dose reduction is recommended; may also consider adjusting the dosing frequency. Note: Dystonias may appear earlier in benserazide/levodopa therapy than with levodopa alone.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions reported in adults. Also see levodopa monograph.

>10%: Nervous system: Involuntary body movements (≥30%; including athetosis, choreiform movements, dystonia), psychiatric disturbance (20%; including dementia, depression [including depression with suicidal tendencies], paranoid ideation, psychotic reaction)

Postmarketing:

Cardiovascular: Angina pectoris, cardiac arrhythmias, ECG changes (nonspecific), edema, flushing, hypertension, orthostatic hypotension, phlebitis

Dermatologic: Alopecia, dark sweat, diaphoresis, pallor, pruritus, skin rash

Endocrine & metabolic: Change in libido (including increased libido with serious antisocial behavior), increased lactate dehydrogenase, increased protein-bound iodine, increased uric acid, weight changes

Gastrointestinal: Abdominal distress, abdominal pain, ageusia, anorexia, bitter taste, bruxism, constipation, diarrhea, discoloration of saliva, duodenal ulcer, dysphagia, epigastric discomfort, epigastric pain, eructation, flatulence, gastrointestinal hemorrhage, hiccups, nausea, oral mucosa changes (discoloration and staining), sialorrhea, staining of tooth, tongue discoloration, vomiting, xerostomia

Genitourinary: Hematuria, nocturia, urinary frequency, urinary incontinence, urinary retention, urine discoloration (including dark urine)

Hematologic & oncologic: Agranulocytosis, hemolytic anemia, leukopenia, positive direct Coombs' test, thrombocytopenia

Hepatic: Increased gamma-glutamyl transferase, increased serum alanine aminotransferase, increased serum alkaline phosphatase, increased serum aspartate aminotransferase, increased serum bilirubin

Nervous system: Abnormal gait, agitation, akinesia (end of dose and akinesia paradoxica), anxiety, asthenia, ataxia, confusion, daytime sedation, delusion, disorientation, dizziness, dopamine dysregulation syndrome, drowsiness, euphoria, fatigue, glosspyrosis, hallucination, headache, Horner syndrome (activation of latent), insomnia, lethargy, malaise, nightmares, numbness, on-off phenomenon, sedated state, seizure, sensation of tightness (mouth, lips, tongue), sense of stimulation, sleep driving, sudden onset of sleep, trismus

Neuromuscular & skeletal: Dyskinesia, lower back pain, lupus-like syndrome (Massarotti 1979), muscle spasm, muscle twitching, musculoskeletal pain, torticollis, tremor of hands (increased)

Ophthalmic: Blepharospasm, blurred vision, diplopia, mydriasis, oculogyric crisis

Renal: Increased blood urea nitrogen

Respiratory: Cough, hoarseness, irregular breathing, post nasal drip

Miscellaneous: Fever

Contraindications

Hypersensitivity to benserazide, levodopa, or any component of the formulation; use with or within 14 days of MAO inhibitors; when administration of a sympathomimetic amine (eg, epinephrine, norepinephrine, isoproterenol) is contraindicated; clinical or laboratory evidence of decompensated cardiovascular, endocrine, renal, hepatic, hematologic, or pulmonary disease; psychiatric diseases with a psychotic component; angle-closure glaucoma; patients <25 years of age; pregnancy or use in women of childbearing potential without adequate contraception

Significant drug interactions exist, requiring dose/frequency adjustment or avoidance. Consult drug interactions database for more information.

Warnings/Precautions

Concerns related to adverse effects:

• CNS effects: [Canadian Boxed Warning]: Patients have reported falling asleep while engaging in activities of daily living including the driving of a car; in some cases, these events have occurred without significant warning signs. Monitor for daytime somnolence or preexisting sleep disorder; discontinue if significant daytime sleepiness or episodes of falling asleep occur. Patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving). Use with caution in patients receiving other CNS depressants or psychoactive agents. Effects with other sedative drugs or ethanol may be potentiated.

• Hypersensitivity: Hypersensitivity reactions may occur in susceptible patients.

• Impulse control disorders: Dopamine agonists used for Parkinson disease or restless legs syndrome have been associated with compulsive behaviors and/or loss of impulse control, which has manifested as pathological gambling, libido increases (hypersexuality), and/or binge eating. Causality has not been established, and controversy exists as to whether this phenomenon is related to the underlying disease, prior behaviors/substance use disorders and/or drug therapy. Dose reduction or discontinuation of therapy has been reported to reverse these behaviors in some, but not all cases.

• Increased growth hormone levels: May increase human growth hormone levels.

Disease-related concerns:

• Cardiovascular disease: Use with caution in patients with cardiovascular disease (MI, atrial, nodal, or ventricular arrhythmias); initiate in a monitored setting. Use is contraindicated in decompensated cardiovascular disease.

• Diabetes: Use with caution in patients with diabetes mellitus; monitor blood glucose frequently. Antidiabetic agents may require dose adjustment.

• Glaucoma: Use with caution in patients with chronic wide-angle glaucoma; monitor IOP carefully. Use is contraindicated in patients with angle-closure glaucoma.

• Hepatic impairment: Use with caution in patients with hepatic impairment. Use is contraindicated in decompensated hepatic disease.

• Peptic ulcer disease: Use with caution in patients with peptic ulcer disease.

• Psychotic disorders: Use with extreme caution in patients with a history of psychotic disorders; observe patients closely for development of depression with concomitant suicidal tendencies. May also cause hallucinations and confusion.

• Renal impairment: Use with caution in patients with renal impairment. Use is contraindicated in decompensated renal disease.

• Seizure disorder: Use with caution in patients with a history of seizure disorder.

Special populations:

• Older adult: Use with caution in the elderly; may be more sensitive to CNS effects of levodopa.

• Perioperative patients: Continue therapy as close to surgical procedures as possible in patients requiring general anesthesia (excluding halothane-risk of blood pressure fluctuations and/or arrhythmias; discontinue benserazide/levodopa 12 to 48 hours before procedure); resume therapy postoperatively with a gradual increase in dose up to that established preoperatively.

• Young adults: Use is contraindicated in patients <25 years of age. Animal data suggests the possibility of skeletal abnormalities if benserazide is administered before ossification is complete.

Other warnings/precautions:

• Abuse: May induce dopaminergic dysregulation syndrome resulting in excessive use of benserazide/levodopa beyond prescribed doses, particularly in males with early onset Parkinson disease (Giovannoni 2000); may lead to cognitive and behavioral disturbances. Monitor for excessive use if cognitive/behavioral disturbances develop.

• Appropriate use: Not indicated in management of intention tremor, Huntington's chorea, or drug-induced extrapyramidal symptoms. Administer in careful increments and observe closely for development of abnormal involuntary movements.

• Discontinuation of therapy: Avoid abrupt withdrawal of therapy; dopaminergic agents have been associated with a syndrome resembling neuroleptic malignant syndrome (NMS) on abrupt withdrawal or significant dosage reduction after long-term use. Withdraw therapy gradually and monitor closely; symptomatic patients should be treated appropriately and if necessary resumption of benserazide/levodopa therapy may be considered.

Product Availability

Not available in the United States.

Generic Equivalent Available: US

Yes

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Capsule, Oral:

Prolopa 100-25: levodopa 100 mg and benserazide 25 mg

Prolopa 200-50: levodopa 200 mg and benserazide 50 mg

Prolopa 50-12.5: levodopa 50 mg and benserazide 12.5 mg

Administration: Adult

Oral: Administer with or immediately after a non-protein or low-protein snack (eg, fruit, applesauce, biscuits) to control GI side effects. Capsules should be swallowed whole; do not crush, chew, open, or dissolve in liquid.

Use: Labeled Indications

Note: Not approved in the United States.

Parkinson disease: Treatment of Parkinson disease (except drug-induced Parkinsonism)

Use: Off-Label: Adult

Parkinsonism (including corticobasal degeneration, dementia with Lewy bodies, drug-induced parkinsonism, multiple system atrophy, and progressive supranuclear palsy); Restless legs syndrome, intermittent

Medication Safety Issues
High alert medication:

The Institute for Safe Medication Practices (ISMP) includes this medication among its list of drug classes (anti-Parkinson agent; contraindicated in pregnancy) which have a heightened risk of causing significant patient harm when used in error (High-Alert Medications in Long-Term Care Settings).

Safety concerns:

ALERT: Canadian Boxed Warning: Health Canada-approved labeling includes a boxed warning. See Warnings/Precautions section for a concise summary of this information. For verbatim wording of the boxed warning, consult the product labeling.

Metabolism/Transport Effects

Refer to individual components.

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.

Alcohol (Ethyl): May increase serum concentration of Levodopa. Risk X: Avoid

Alfuzosin: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Alizapride: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk X: Avoid

Amifostine: Blood Pressure Lowering Agents may increase hypotensive effects of Amifostine. Management: When used at chemotherapy doses, hold blood pressure lowering medications for 24 hours before amifostine administration. If blood pressure lowering therapy cannot be held, do not administer amifostine. Use caution with radiotherapy doses of amifostine. Risk D: Consider Therapy Modification

Amisulpride (Injection): May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk X: Avoid

Amisulpride (Oral): Anti-Parkinson Agents (Dopamine Agonist) may decrease therapeutic effects of Amisulpride (Oral). Amisulpride (Oral) may decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk X: Avoid

Antipsychotic Agents (First Generation [Typical]): May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Management: Avoid concomitant therapy if possible. If antipsychotic use is necessary, consider using atypical antipsychotics such as clozapine, quetiapine, or ziprasidone at lower initial doses, or a non-dopamine antagonist (eg, pimavanserin). Risk D: Consider Therapy Modification

Antipsychotic Agents (Second Generation [Atypical]): May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Management: Consider avoiding atypical antipsychotic use in patients with Parkinson disease. If an atypical antipsychotic is necessary, consider using clozapine, quetiapine, or ziprasidone at lower initial doses, or a non-dopamine antagonist (eg, pimavanserin). Risk D: Consider Therapy Modification

Arginine: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Barbiturates: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Biperiden: May increase adverse/toxic effects of Levodopa-Foslevodopa. Specifically, the risk of choreic movements or dyskinesias may be increased. Risk C: Monitor

Blood Pressure Lowering Agents: May increase hypotensive effects of Hypotension-Associated Agents. Risk C: Monitor

Blood Pressure Lowering Agents: May increase hypotensive effects of Levodopa-Foslevodopa. Risk C: Monitor

Bornaprine: May increase adverse/toxic effects of Levodopa-Foslevodopa. Specifically, dyskinesia may be increased. Risk C: Monitor

Brimonidine (Topical): May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Brivudine: May increase adverse/toxic effects of Anti-Parkinson Agents (Dopamine Agonist). Specifically, the risk of chorea may be increased. Risk C: Monitor

Bromopride: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk C: Monitor

Bromperidol: May decrease hypotensive effects of Blood Pressure Lowering Agents. Blood Pressure Lowering Agents may increase hypotensive effects of Bromperidol. Risk X: Avoid

BuPROPion: Anti-Parkinson Agents (Dopamine Agonist) may increase adverse/toxic effects of BuPROPion. Risk C: Monitor

Diazoxide: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

DULoxetine: Blood Pressure Lowering Agents may increase hypotensive effects of DULoxetine. Risk C: Monitor

Fluorodopa F18: Coadministration of Anti-Parkinson Agents (Dopamine Agonist) and Fluorodopa F18 may alter diagnostic results. Management: Discontinue medications used to treat Parkinson disease, including dopamine agonists, 12 hours prior to fluorodopa F 18 administration if these medications can be safely withheld. Risk D: Consider Therapy Modification

Fosphenytoin-Phenytoin: May decrease therapeutic effects of Levodopa-Foslevodopa. Risk C: Monitor

Glycopyrrolate (Systemic): May decrease serum concentration of Levodopa-Foslevodopa. Risk C: Monitor

Herbal Products with Blood Pressure Lowering Effects: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Hypotension-Associated Agents: Blood Pressure Lowering Agents may increase hypotensive effects of Hypotension-Associated Agents. Risk C: Monitor

Iron Preparations: May decrease serum concentration of Levodopa. Only applies to oral iron preparations. Management: Consider separating doses of the agents by 2 or more hours to minimize the effects of this interaction. Monitor for decreased therapeutic effects of levodopa during concomitant therapy, particularly if doses cannot be separated. Risk D: Consider Therapy Modification

Isoniazid: May decrease therapeutic effects of Levodopa-Foslevodopa. Risk C: Monitor

Kava Kava: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Kava Kava may increase adverse/toxic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk C: Monitor

Levodopa-Foslevodopa: Blood Pressure Lowering Agents may increase hypotensive effects of Levodopa-Foslevodopa. Risk C: Monitor

Lormetazepam: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Macimorelin: Coadministration of Levodopa-Foslevodopa and Macimorelin may alter diagnostic results. Risk X: Avoid

Metergoline: May increase adverse/toxic effects of Levodopa-Foslevodopa. Management: Consider the need for possible reductions in levodopa dose with initiation of or increasing doses of metergoline. Monitor for evidence of increased levodopa adverse effects with use of the combination. Risk D: Consider Therapy Modification

Methotrimeprazine: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Anti-Parkinson Agents (Dopamine Agonist) may decrease therapeutic effects of Methotrimeprazine. Risk X: Avoid

Metoclopramide: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk X: Avoid

Molsidomine: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Monoamine Oxidase Inhibitors (Type B): Levodopa-Foslevodopa may increase orthostatic hypotensive effects of Monoamine Oxidase Inhibitors (Type B). Risk C: Monitor

Monoamine Oxidase Inhibitors: Levodopa-Foslevodopa may increase adverse/toxic effects of Monoamine Oxidase Inhibitors. Of particular concern is the development of hypertensive reactions when levodopa is used with nonselective MAOI. Risk X: Avoid

Multivitamins/Fluoride (with ADE): May decrease therapeutic effects of Levodopa-Foslevodopa. Management: Concurrent use of a multivitamin and levodopa (without carbidopa) should be avoided. Risk D: Consider Therapy Modification

Multivitamins/Minerals (with ADEK, Folate, Iron): May decrease therapeutic effects of Levodopa. Multivitamins/Minerals (with ADEK, Folate, Iron) may decrease serum concentration of Levodopa. Only applies to oral iron-containing preparations. Management: Separate doses of these agents by 2 or more hours. Monitor for decreased levodopa effects, particularly if doses cannot be separated. Concurrent use of a multivitamin and levodopa (without carbidopa) should be avoided. Risk D: Consider Therapy Modification

Multivitamins/Minerals (with AE, No Iron): May decrease therapeutic effects of Levodopa-Foslevodopa. Management: Concurrent use of a multivitamin and levodopa (without carbidopa) should be avoided. Risk D: Consider Therapy Modification

Naftopidil: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Nicergoline: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Nicorandil: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Nitroprusside: Blood Pressure Lowering Agents may increase hypotensive effects of Nitroprusside. Risk C: Monitor

Obinutuzumab: May increase hypotensive effects of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Risk D: Consider Therapy Modification

Papaverine: May decrease therapeutic effects of Levodopa-Foslevodopa. Papaverine may increase hypotensive effects of Levodopa-Foslevodopa. Risk C: Monitor

Pentoxifylline: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Pholcodine: Blood Pressure Lowering Agents may increase hypotensive effects of Pholcodine. Risk C: Monitor

Phosphodiesterase 5 Inhibitors: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Prostacyclin Analogues: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Pyridoxine: May decrease therapeutic effects of Levodopa-Foslevodopa. Management: The concomitant use of pyridoxine and levodopa (in the absence of a dopa decarboxylase inhibitor (DDI)) should be avoided. Use of a DDI (eg, carbidopa) with levodopa will essentially eliminate the risk of this interaction. Risk D: Consider Therapy Modification

Quinagolide: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Reserpine: Levodopa-Foslevodopa may increase hypotensive effects of Reserpine. Reserpine may decrease therapeutic effects of Levodopa-Foslevodopa. Management: Consider alternatives to the coadministration of levodopa and reserpine. If combined, monitor for reduced levodopa efficacy and hypotension. Risk D: Consider Therapy Modification

Sapropterin: May increase adverse/toxic effects of Levodopa-Foslevodopa. Risk C: Monitor

Silodosin: May increase hypotensive effects of Blood Pressure Lowering Agents. Risk C: Monitor

Solriamfetol: May increase adverse/toxic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk C: Monitor

Sulpiride: May decrease therapeutic effects of Anti-Parkinson Agents (Dopamine Agonist). Risk X: Avoid

Tiapride: Levodopa-Foslevodopa may decrease therapeutic effects of Tiapride. Tiapride may decrease therapeutic effects of Levodopa-Foslevodopa. Risk X: Avoid

Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors: May decrease therapeutic effects of Levodopa-Foslevodopa. Management: Consider alternatives to the coadministration of levodopa and vesicular monoamine transporter 2 (VMAT2) inhibitors. If combined, monitor for reduced levodopa efficacy. Risk D: Consider Therapy Modification

Food Interactions

High protein diets have the potential to impair levodopa absorption; levodopa competes with certain amino acids for transport across the gut wall or across the blood-brain barrier. Management: Avoid high protein diets.

Food reduces the extent of levodopa absorption by 15% and peak plasma concentrations by 30%. Management: Administer with or immediately after meals.

Reproductive Considerations

Use is contraindicated in women of childbearing potential not using proper contraception.

Pregnancy Considerations

Use is contraindicated during pregnancy.

Levodopa crosses the placenta and can be metabolized by the fetus and detected in fetal tissue (Merchant 1995). The incidence of Parkinson disease in pregnancy is relatively rare and information related to the use of benserazide/levodopa in pregnant women is limited (Hagell 1998; von Graevenitz 1996). The manufacturer recommends that women who become pregnant during therapy gradually taper off therapy; avoid abrupt withdrawal.

Breastfeeding Considerations

Levodopa is present in breast milk (based on a study using carbidopa/levodopa) (Thulin 1998); excretion of benserazide is not known. Breastfeeding is not recommended by the manufacturer.

Dietary Considerations

High-protein diets may decrease effect of levodopa.

Monitoring Parameters

Regular assessment of cardiovascular, hepatic, hematopoietic, and renal function with initiation and during dose stabilization then periodically with extended therapy; blood glucose frequently in patients with diabetes; symptoms of psychosis and dystonia

Mechanism of Action

Symptoms of Parkinson disease are due to a lack of striatal dopamine. Levodopa crosses into the blood-brain barrier (BBB) and is converted to dopamine by striatal enzymes. Benserazide inhibits the peripheral plasma breakdown of levodopa by inhibiting its decarboxylation and therefore increases levodopa availability at the BBB.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Benserazide: 66% to 74%

Distribution:

Benserazide: Does not cross the blood-brain barrier; mainly concentrated in kidneys, liver, lungs, and small intestine

Levodopa: 57 L; crosses the blood-brain barrier and not bound to plasma proteins

Metabolism:

Benserazide: Hydroxylated in the intestine and liver to trihydroxybenzylhydrazine, a potent inhibitor of decarboxylase

Levodopa: Major pathways: Decarboxylation to dopamine and O-methylation to 3-O-methyldopa; Minor pathways; Transamination and oxidation

Bioavailability: Levodopa: 98% (range: 74% to 112%)

Half-life elimination: Levodopa: 1.5 hours; 3-O-methyldopa (major metabolite): 15 hours

Time to peak, serum: Levodopa: ~1 hour

Excretion: Benserazide: Urine (64%); feces (24%); Levodopa: Urine (as metabolites)

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Madopar;
  • (AR) Argentina: Madopar | Madopar hbs;
  • (AT) Austria: Madopar | Madopar cr | Restex;
  • (AU) Australia: Madopar;
  • (BD) Bangladesh: Benkinson;
  • (BE) Belgium: Prolopa;
  • (BG) Bulgaria: Madopar | Madopar hbs | Menkart;
  • (BR) Brazil: Ekson | Lebens | Levodopa + cloridrato de benserazida | Levrasida | Prolopa | Prolopa hbs;
  • (CH) Switzerland: Levodopa/benserazid devatis | Madopar | Madopar dr | Madopar hbs | Madopar LIQ 62.5;
  • (CL) Chile: Levibense | Madozide | Melitase | Prolopa;
  • (CN) China: L-dopa+benserazide | Levodopa and benserazide hydrochloride | Madopar;
  • (CO) Colombia: Madopar;
  • (CZ) Czech Republic: Levodopa benserazide Teva | Madopar | Madopar hbs;
  • (DE) Germany: Dopadura B | Levobens Teva | Levodopa Benserazid beta | Levodopa benserazide | Levodopa Benserazide CT | Levodopa comp b | Levodopa plus benserazid AL | Levodopa/benserazid neuraxpharm | Levodopa/Benserazide Devatis | Levopar | Madopar | Madopar Depot | Madopar LT | Pk Levo | Prolopa | Restex;
  • (DK) Denmark: Madopar;
  • (DO) Dominican Republic: Prolopa;
  • (EC) Ecuador: Madopar | Prolopa;
  • (EE) Estonia: Aktipar | Madopar | Madopar hbs;
  • (ES) Spain: Madopar;
  • (FI) Finland: Aktipar | Levodopa/benserazide orifarm | Madopar;
  • (FR) France: Levodopa benserazide Teva | Modopar | Modopar lp;
  • (GB) United Kingdom: Co-Beneldopa | Madopar;
  • (GR) Greece: Levodopa+benserazide/teva | Madopar | Madopar hbs;
  • (HK) Hong Kong: Madopar;
  • (HR) Croatia: Madopar;
  • (HU) Hungary: Madopar;
  • (ID) Indonesia: Leparson | Levazide | Levoben | Levopar | Madopar | Madopar dispersible | Pardoz;
  • (IE) Ireland: Madopar;
  • (IL) Israel: Levopar plus;
  • (IN) India: Madopar;
  • (IT) Italy: Madopar;
  • (JP) Japan: Ec doparl | Madopar | Neodopasol;
  • (KR) Korea, Republic of: Madopar | Madopar hbs | Myungdopar | R.b.p;
  • (LB) Lebanon: Madopar;
  • (LT) Lithuania: Madopar | Madopar hbs;
  • (LU) Luxembourg: Prolopa;
  • (LV) Latvia: Madopar | Madopar hbs;
  • (MA) Morocco: Madopar | Modopar;
  • (MX) Mexico: Madopar;
  • (MY) Malaysia: Madopar;
  • (NL) Netherlands: Levodopa/benserazide | Levodopa/Benserazide PCH | Madopar | Modopar;
  • (NO) Norway: Madopar;
  • (NZ) New Zealand: Levodopa/benserazide | Madopar;
  • (PE) Peru: Hardal | Levosta | Madopar | Madopar hbs | Madozide;
  • (PH) Philippines: Madopar | Madopar hbs;
  • (PK) Pakistan: Madopar;
  • (PL) Poland: Madopar | Xevoben | Xevoben xr;
  • (PT) Portugal: Madopar | Madopar hbs;
  • (PY) Paraguay: Madopar | Madopar hbs | Madozide | Melitase | Prolopa | Prolopa hbs | Seler;
  • (QA) Qatar: Madopar;
  • (RO) Romania: Levodopa/benserazide teva;
  • (RU) Russian Federation: Benziel | Levodopa benserazide | Levodopa/benserazide teva | Madopar | Madopar gss | Madopar hbs;
  • (SA) Saudi Arabia: Madopar;
  • (SE) Sweden: Levodopa/Benserazid Ebb | Levodopa/benserazid ratiopharm | Levodopa/benserazide 2care4 | Levodopa/benserazide orifarm | Madopar | Madopar Depot | Madopar Quick | Madopar Quick mite | Madopark | Madopark depot | Madopark quick;
  • (SG) Singapore: Madopar;
  • (SI) Slovenia: Madopar;
  • (SK) Slovakia: Madopar | Madopar hbs;
  • (SR) Suriname: Levodopa/benserazide | Levodopa/Benserazide PCH | Levodopa/benserazide teva | Prolopa;
  • (TH) Thailand: Levopar | Madopar | Vopar;
  • (TN) Tunisia: Modopar;
  • (TR) Turkey: Domirpa | Madopar;
  • (TW) Taiwan: Bendopa | Bendopar | Madopar;
  • (UA) Ukraine: Madopar;
  • (UY) Uruguay: Levodopa C | Prolopa | Prolopa hbs | Seler | Tonotil;
  • (VE) Venezuela, Bolivarian Republic of: Madopar;
  • (VN) Viet Nam: Levobenserazid vmg;
  • (ZA) South Africa: Madopar
  1. Aurora RN, Kristo DA, Bista SR, et al; American Academy of Sleep Medicine. The treatment of restless legs syndrome and periodic limb movement disorder in adults--an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine clinical practice guideline. Sleep. 2012;35(8):1039-1062. doi:10.5665/sleep.1988 [PubMed 22851801]
  2. Benes H, Kurella B, Kummer J, Kazenwadel J, Selzer R, Kohnen R. Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial. Sleep. 1999;22(8):1073-1081. doi:10.1093/sleep/22.8.1073 [PubMed 10617168]
  3. Collins SJ, Ahlskog JE, Parisi JE, Maraganore DM. Progressive supranuclear palsy: neuropathologically based diagnostic clinical criteria. J Neurol Neurosurg Psychiatry. 1995;58(2):167-173. doi:10.1136/jnnp.58.2.167 [PubMed 7876846]
  4. Garcia-Borreguero D, Ferini-Strambi L, Kohnen R, et al; European Federation of Neurological Societies; European Neurological Society; European Sleep Research Society. European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. Eur J Neurol. 2012;19(11):1385-1396. doi:10.1111/j.1468-1331.2012.03853.x [PubMed 22937989]
  5. Garcia-Borreguero D, Silber MH, Winkelman JW, et al Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016;21:1-11. doi:10.1016/j.sleep.2016.01.017 [PubMed 27448465]
  6. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology. 2008;71(9):670-676. doi:10.1212/01.wnl.0000324625.00404.15 [PubMed 18725592]
  7. Giovannoni G, O’Sullivan JD, Turner K, et al. Hedonistic homeostatic dysregulation in patients with Parkinson’s disease on dopamine replacement therapies. J Neurol Neurosurg Psychiatry. 2000;68(4):423-428. [PubMed 10727476]
  8. Goldman JG, Goetz CG, Brandabur M, Sanfilippo M, Stebbins GT. Effects of dopaminergic medications on psychosis and motor function in dementia with Lewy bodies. Mov Disord. 2008;23(15):2248-2250. doi:10.1002/mds.22322 [PubMed 18823039]
  9. Grimes D, Fitzpatrick M, Gordon J, et al. Canadian guideline for Parkinson disease. CMAJ. 2019;191(36):E989-E1004. doi:10.1503/cmaj.181504 [PubMed 31501181]
  10. Hagell P, Odin P, and Vinge E. Pregnancy in Parkinson's disease: a review of the literature and a case report. Mov Disord. 1998;13(1):34-38. [PubMed 9452323]
  11. Hardie RJ, Lees AJ. Neuroleptic-induced Parkinson's syndrome: clinical features and results of treatment with levodopa. J Neurol Neurosurg Psychiatry. 1988;51(6):850-854. doi:10.1136/jnnp.51.6.850 [PubMed 2900293]
  12. Höglinger GU, Respondek G, Stamelou M, et al; Movement Disorder Society-endorsed PSP Study Group. Clinical diagnosis of progressive supranuclear palsy: the Movement Disorder Society criteria. Mov Disord. 2017;32(6):853-864. doi:10.1002/mds.26987 [PubMed 28467028]
  13. Kompoliti K, Goetz CG, Boeve BF, et al. Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol. 1998;55(7):957-961. doi:10.1001/archneur.55.7.957 [PubMed 9678313]
  14. Ling H, O'Sullivan SS, Holton JL, et al. Does corticobasal degeneration exist? A clinicopathological re-evaluation. Brain. 2010;133(pt 7):2045-2057. doi:10.1093/brain/awq123 [PubMed 20584946]
  15. Low PA, Reich SG, Jankovic J, et al. Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol. 2015;14(7):710-719. doi:10.1016/S1474-4422(15)00058-7 [PubMed 26025783]
  16. Massarotti G, Cassi E, Passaleva A. Lupus-like autoimmune syndrome after levodopa and benserazide. Br Med J. 1979;2(6189):553. doi:10.1136/bmj.2.6189.553 [PubMed 497698]
  17. Merchant CA, Cohen G, Mytilineou C, et al. Human transplacental transfer of carbidopa/levodopa. J Neural Transm Park Dis Dement Sect. 1995;9(2-3):239-422. [PubMed 8527007]
  18. Molina JA, Sàinz-Artiga MJ, Fraile A, et al. Pathologic gambling in Parkinson's disease: a behavioral manifestation of pharmacologic treatment. Mov Disord. 2000;15(5):869-872. [PubMed 11009192]
  19. Molloy S, McKeith IG, O'Brien JT, Burn DJ. The role of levodopa in the management of dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2005;76(9):1200-1203. doi:10.1136/jnnp.2004.052332 [PubMed 16107351]
  20. Oliver D, Veronese S. Palliative approach to Parkinson disease and parkinsonian disorders. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed August 31, 2021.
  21. Prolopa (levodopa/benserazide) [product monograph]. Mississauga, Ontario, Canada: Hoffman-La Roche Limited; August 2019.
  22. Serrano-Dueñas M. Neuroleptic malignant syndrome-like, or--dopaminergic malignant syndrome--due to levodopa therapy withdrawal. Clinical features in 11 patients. Parkinsonism Relat Disord. 2003;9(3):175-178. doi:10.1016/s1353-8020(02)00035-4 [PubMed 12573874]
  23. Thulin PC, Woodward WR, Carter JH, et al. Levodopa in human breast milk: clinical implications. Neurology, 1998;50(6):1920-1921. [PubMed 9633767]
  24. Tinazzi M, Antonini A, Bovi T, et al. Clinical and [123I]FP-CIT SPET imaging follow-up in patients with drug-induced parkinsonism. J Neurol. 2009;256(6):910-915. doi:10.1007/s00415-009-5039-0 [PubMed 19252795]
  25. von Graevenitz KS, Shulman LM, and Revell SP. Levodopa in pregnancy. Mov Disord. 1996;11(1):115-116. [PubMed 8771087]
Topic 9796 Version 215.0