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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : -12 مورد

Clinical and laboratory manifestations of Ebola virus disease

Clinical and laboratory manifestations of Ebola virus disease
Stage of illness Time post-symptom onset Clinical Laboratory
Early febrile Days 1-3 Fever, malaise, fatigue, body aches Leukopenia, lymphopenia, thrombocytopenia, elevated AST and ALT
Gastrointestinal Days 3-10

Primary: Epigastric and abdominal pain, nausea, vomiting, diarrhea

Associated: Persistent fever, asthenia, headache, conjunctival injection, chest pain, dysphagia, odynophagia, arthralgias, myalgias, hiccups, delirium, and rash

Persistently elevated AST/ALT and thrombocytopenia

Elevated BUN and creatinine

Hypokalemia, hypomagnesemia, hyponatremia, hypoalbuminemia

Elevated PT/PTT/INR/fibrin-split products

Leukocytosis (elevated neutrophils and band cells)

Shock Days 7-12 Diminished consciousness or coma, thready pulse, oliguria, anuria, tachypnea In addition to findings during gastrointestinal stage: Elevated lactate, decreased bicarbonate
Other complications Day 10 and after Gastrointestinal hemorrhage, respiratory failure associated with aggressive fluid resuscitation or lung injury, secondary infections, neurocognitive abnormalities, seizures, syndrome consistent with meningoencephalitis

Findings may overlap with prior stages of illness

Decreased hemoglobin and hematocrit observed with gastrointestinal bleeding

Hypoxemia observed with respiratory failure

Recovery Days 7-12 Resolution of gastrointestinal symptoms, increased oral intake, increased energy Resolution of laboratory abnormalities
Convalescence Up to 12 months Arthralgias, myalgias, abdominal pain, fatigue, persistent neurocognitive abnormalities, uveitis, meningitis, hearing loss  
ALT: alanine aminotransferase; AST: aspartate aminotransferase; BUN: blood urea nitrogen; INR: international normalized ratio; PT: prothrombin time; PTT: partial thromboplastin time.
Courtesy of Daniel S. Chertow, MD, MPH.
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