Version July 2025
| Name | Common brand name(s) and strength | Generic available | Available without a prescription (OTC) | Usual adult dose per nostril | Type of preparation (alcohol content)* |
| Second generation (systemic bioavailability <1% or undetectable) | |||||
| Ciclesonide | Omnaris (50 mcg/spray) | No | No | 2 sprays once daily | Aqueous suspension pump spray |
| Zetonna (37 mcg/spray) | No | No | 1 spray once daily | Pressurized aerosol spray (3.4% alcohol) | |
| Fluticasone furoate | Flonase Sensimist (OTC) (27.5 mcg/spray) | No | Yes | 2 sprays once daily | Aqueous suspension pump spray |
| Fluticasone propionate | Flonase Allergy Relief (OTC) (50 mcg/spray) | Yes | Yes | 2 sprays once daily or 1 spray twice daily | Aqueous suspension pump spray (0.25% alcohol) |
| Mometasone | Nasonex 24HR Allergy (OTC) (50 mcg/spray) | Yes | Yes | 2 sprays once daily | Aqueous suspension pump spray |
| First generation (systemic bioavailability 10 to 50%) | |||||
| Beclomethasone | Qnasl (80 mcg/spray) | No | No | 2 sprays once daily | Pressurized aerosol spray (8% alcohol) |
| Beconase AQ (50 mcg/spray) Available in some areas (not US or Canada) | No | No | 1 to 2 sprays twice daily | Aqueous suspension pump spray (0.25% alcohol) | |
| Budesonide | Generic (formerly Rhinocort Allergy) (OTC) (32 mcg/spray) | Yes | Yes | 1 to 2 sprays once daily | Aqueous suspension pump spray |
| Flunisolide | Generic (formerly Nasalide) (25 mcg/spray) | Yes | No | 2 sprays 2 or 3 times daily (maximum 2 sprays 4 times daily) | Aqueous suspension pump spray (contains propylene glycol, a possible irritant) |
| Triamcinolone | GoodSense Nasal Allergy (OTC), Nasacort Allergy 24HR (OTC) (55 mcg/spray) | Yes | Yes | 2 sprays once daily | Aqueous suspension pump spray |
Nasal sprays work best when they are administered properly and the medication remains in the nose rather than draining down the back of the throat. Note that the recommended techniques for the aqueous and aerosol sprays are different. If the nose is crusted or contains mucus, it should first be cleaned with a saline nasal spray prior to use of intranasal sprays. Some people find that holding the other nostril closed with a finger improves their ability to draw the spray into the upper nose.
Once symptoms are controlled, the daily dose can be reduced to the lowest dose that maintains control.
Dosing and product descriptions are based upon products available in the United States and some other countries. Product descriptions in other countries may differ in some detail. Consult the UpToDate Lexidrug monographs and local product information for additional detail.
OTC: over the counter (available without a prescription in the United States and some other countries).
* Alcohol may contribute to dryness or irritation.
